Evidence map›Paper›PMID 39071980›Full record

ArticleNeurotrauma reports2024

Management of Pediatric Mild Traumatic Brain Injury Patients: S100b, Glial Fibrillary Acidic Protein, and Heart Fatty-Acid-Binding Protein Promising Biomarkers.

Anne-Cécile Chiollaz, Virginie Pouillard, Fabian Spigariol, Fabrizio Romano, Michelle Seiler, Céline Ritter Schenk, Christian Korff, Céline Habre, Fabienne Maréchal, Verena Wyss and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Anne-Cécile ChiollazInternal Medicine Department, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Virginie PouillardPediatric Neurology Unit, Woman, Child and Adolescent Department, Geneva University Hospitals, Geneva, Switzerland.
Fabian SpigariolPediatric Emergency Department, Neuchâtel Hospital (RHNE), Neuchatel, Switzerland.
Fabrizio RomanoDivision of Pediatric Emergency Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Michelle SeilerPediatric Emergency Department, University Children's Hospital Zurich, Zurich, Switzerland.
Céline Ritter SchenkDepartment of Pediatrics, Fribourg Hospital HFR, Fribourg, Switzerland.
Christian KorffPediatric Neurology Unit, Woman, Child and Adolescent Department, Geneva University Hospitals, Geneva, Switzerland.
Céline HabreDivision of Radiology, University Hospitals of Geneva, Geneva, Switzerland.
Fabienne MaréchalPlatform of Pediatric Clinical Research, Woman, Child and Adolescent Department, Geneva University Hospitals, Geneva, Switzerland.
Verena WyssDivision of Pediatric Emergency Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Lyssia GruazInternal Medicine Department, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Marcel Lamana-VallverduNeurovascular Research Laboratory, Vall d'Hebron Institute of Research, Autonomous University of Barcelona, Barcelona, Spain.
Elvira ChocanoNeurovascular Research Laboratory, Vall d'Hebron Institute of Research, Autonomous University of Barcelona, Barcelona, Spain.
Lluis Sempere BordesNeurovascular Research Group, Institute of Biomedicine in Sevilla, Sevilla, Spain.
Carlos Luaces-CubellsPediatric Emergency Service, University Hospital San Joan de Deu, Esplugues del Llobregat, Barcelona, Spain.
María Méndez-HernándezPediatric Service, University Hospital Germans Trias i Pujol, Barcelona, Spain.
José Antonio Alonso CadenasPediatric Department, University Hospital Niño Jesús, Madrid, Spain.
María José Carpio LindePediatric Emergency Service, University Hospital Virgen de la Macarena, Sevilla, Spain.
Paula de la Torre SanchezPediatric Emergency Service, University Hospital Virgen de la Macarena, Sevilla, Spain.
BIOTRABIS investigators and participants, t-BIOMAP investigators and participants,
BIOTRABIS investigators and participants, t-BIOMAP investigators and participants

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children are highly vulnerable to mild traumatic brain injury (mTBI). Blood biomarkers can help in their management. This study evaluated the performances of biomarkers, in discriminating between children with mTBI who had intracranial injuries (ICIs) on computed tomography (CT+) and (1) patients without ICI (CT-) or (2) both CT- and in-hospital-observation without CT patients. The aim was to rule out the need of unnecessary CT scans and decrease the length of stay in observation in the emergency department (ED). Newborns to teenagers (≤16 years old) with mTBI (Glasgow Coma Scale > 13) were included. S100b, glial fibrillary acidic protein (GFAP), and heart fatty-acid-binding protein (HFABP) performances to identify patients without ICI were evaluated through receiver operating characteristic curves, where sensitivity was set at 100%. A total of 222 mTBI children sampled within 6 h since their trauma were reported. Nineteen percent (

Indexed as

biomarkersdiagnosticsemergencymild traumatic brain injury (mTBI)pediatrictriage

Identifiers

PMID39071980
PMCPMC11271147

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.