Evidence map›Paper›PMID 39071953›Full record

ArticleMolecular therapy. Nucleic acids2024

Functional benefit of CRISPR-Cas9-induced allele deletion for

Mathilde Beaufils, Margaux Melka, Julie Brocard, Clement Benoit, Nagi Debbah, Kamel Mamchaoui, Norma B Romero, Anne Frédérique Dalmas-Laurent, Susana Quijano-Roy, Julien Fauré and 2 more

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mathilde BeaufilsUniversity Grenoble Alpes, INSERM, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000 Grenoble, France.
Margaux MelkaUniversity Grenoble Alpes, INSERM, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000 Grenoble, France.
Julie BrocardUniversity Grenoble Alpes, INSERM, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000 Grenoble, France.
Clement BenoitUniversity Grenoble Alpes, TIMC, CNRS UMR5525, 38000 Grenoble, France.
Nagi DebbahUniversity Grenoble Alpes, INSERM, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000 Grenoble, France.
Kamel MamchaouiSorbonne Université, INSERM, Institut de Myologie, Centre de Recherche en Myologie, 75000 Paris, France.
Norma B RomeroNeuromuscular Morphology Unit, Institut de Myologie, Pitié-Salpêtrière Hospital, Sorbonne Université, 75000 Paris, France.
Anne Frédérique Dalmas-LaurentMH Unit, Lille University Hospital, 59000 Lille, France.
Susana Quijano-RoyNeuromuscular Unit (NEIDF), Child Neurology and ICU Department, Raymond-Poincaré Hospital, (APHP University Paris-Saclay), 92380 Garches, France.
Julien FauréUniversity Grenoble Alpes, INSERM, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000 Grenoble, France.
John RenduUniversity Grenoble Alpes, INSERM, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000 Grenoble, France.
Isabelle MartyUniversity Grenoble Alpes, INSERM, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000 Grenoble, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

More than 700 pathogenic or probably pathogenic variations have been identified in the

Indexed as

allele deletioncalcium releaseCRISPR-Cas9dominant mutationgene therapyMT: RNA/DNA Editingmyopathyryanodine receptorSNP

Identifiers

PMID39071953
PMCPMC11278293

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.