ArticleVirusdisease2024
Kinetics of dengue viremia and its association with disease severity: an ambispective study.
Article in Virusdisease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Safety and Preliminary Efficacy of Dengue Monoclonal Antibody in Adult Patients: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Dual readout RT-LAMP for rapid on-site dengue virus detection and serotyping.Microbiology spectrum · 2026Article
- Article
- Acute-Phase Dengue Antibody Profiles in Pediatric Patients: Influence on Viremia and Disease Manifestations.Viruses · 2026Article
- Progression of dengue during an outbreak (2024) in Dhaka, Bangladesh: a hospital based longitudinal study.The Lancet regional health. Southeast Asia · 2026Article
- Low-density granulocytes and neutrophil extracellular traps in dengue, impacts of interferon alpha and cell-free DNA.Scientific reports · 2025Article
- Another Dengue Antiviral Drug Bites the Dust Early: Where Does Dengue Therapeutic Drug Development Go from Here?The American journal of tropical medicine and hygiene · 2025Article
- Risk Stratification of Dengue Cases Requiring Hospitalization.Journal of medical virology · 2025Article
- Dengue and Flavivirus Co-Infections: Challenges in Diagnosis, Treatment, and Disease Management.International journal of molecular sciences · 2025Review
- Emergence of Oropouche Virus in Espírito Santo State, Brazil, 2024.Emerging infectious diseases · 2025Article
- Atypical dengue fever in a partially vaccinated patient: a case report.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dengue virus (DENV) infection is an important public health problem and causes significant morbidity and mortality. DENV typically causes a febrile illness that ranges from mild asymptomatic infection to fatal dengue hemorrhagic fever (DHF) and/or dengue shock syndrome (DSS). Early prediction of severe dengue disease is of utmost importance for providing prompt monitoring and treatment. The search for an ideal biomarker (host or viral factors) for early prediction of severe dengue remains elusive. Aim: To standardize a real time qRT-PCR for quantifying dengue viremia in serum samples and evaluate the kinetics of dengue viremia and its significance in disease severity. Results: In this ambispective study of 126 laboratory confirmed dengue patients, 72 were primary infections and 54 were secondary infections. The most common serotype was serotype 1 (n = 37) followed by serotype 2 (n = 34). According to WHO 1997 dengue case classification, 111 patients were cases of dengue fever (DF), 13 from DHF and 02 from DSS. Day 3 viremia levels were significantly elevated in severe dengue patients (DHF/DSS) as compared to that of DF ( Conclusion: Dengue viremia has a significant association with disease severity and day 3 viremia levels may be used as a predictor for dengue disease severity.
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