Evidence map›Paper›PMID 39071840›Full record

ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2024

Insights into the Correlation between Toll-Like Receptor 2 Polymorphism and HBV-Related Disease Progression and Occurrence of Hepatocellular Carcinoma: A Case-Control Study in Egyptian Patients.

Naglaa S Elabd, Marwa L Helal, Mohsen Elkhayat, Heba Kamal Abd-ElKhalek, Doaa M Ahmed, Asmaa M El-Shemy, Yara S Elsaadawy, Rasha A Abdelmoneum, Hind S AboShabaan, Randa M Seddik

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In one paragraph

Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Naglaa S ElabdDepartment of Tropical Medicine Faculty of Medicine Menoufia University, Shebin El-Kom, Menoufia, Egypt.ORCID https://orcid.org/0000-0001-8786-0190
Marwa L HelalDepartment of Clinical Biochemistry and Molecular Diagnostics National Liver Institute Menoufia University, Shebin El-Kom, Menoufia, Egypt.ORCID https://orcid.org/0000-0001-5406-813X
Mohsen ElkhayatDepartment of Tropical Medicine Faculty of Medicine Menoufia University, Shebin El-Kom, Menoufia, Egypt.
Heba Kamal Abd-ElKhalekDepartment of Internal Medicine Faculty of Medicine Menoufia University, Shebin El-Kom, Menoufia, Egypt.ORCID https://orcid.org/0000-0001-8769-0806
Doaa M AhmedDepartment of Radiology Faculty of Medicine Menoufia University, Shebin El-Kom, Menoufia, Egypt.
Asmaa M El-ShemyDepartment of Clinical Pathology Faculty of Medicine Menoufia University, Shebin El-Kom, Menoufia, Egypt.ORCID https://orcid.org/0000-0002-8040-1589
Yara S ElsaadawyDepartment of Medical Microbiology and Immunology Faculty of Medicine Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0009-0003-2256-6806
Rasha A AbdelmoneumDepartment of Clinical Oncology and Nuclear Medicine Faculty of Medicine Menoufia University, Shebin El-Kom, Menoufia, Egypt.ORCID https://orcid.org/0000-0002-8078-9616
Hind S AboShabaanBiochemistry National Liver Institute Hospital Menoufia University, Shebin El-Kom, Menoufia, Egypt.ORCID https://orcid.org/0009-0007-0390-9454
Randa M SeddikDepartment of Tropical Medicine Faculty of Medicine Menoufia University, Shebin El-Kom, Menoufia, Egypt.ORCID https://orcid.org/0000-0001-9389-7635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods: In total, 170 chronic HBV patients and 50 healthy controls of comparable age and gender were included in this case-control study. Clinical, laboratory, and imaging evaluations were conducted. ELISA was used to determine serum IL-6 levels, and TLR2 (rs3804099) genotyping allelic discrimination assay was performed using real-time PCR. Results: IL-6 values were significantly higher in the HCC group, followed by the cirrhotic group, than those in chronic hepatitis and control groups ( Conclusion: In chronic HBV patients, TRL2 polymorphism and higher IL-6 levels were positively correlated with a higher likelihood of HCC and chronic hepatitis B disease activity and progression.

Identifiers

PMID39071840
PMCPMC11281855

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.