Evidence map›Paper›PMID 39071532›Full record

ArticleClinical Medicine Insights. Oncology2024

Peripheral Coagulation Parameters and Prostate Cancer Association: A Retrospective Study and Mendelian Randomization.

Feifan Liu, Yufeng Song, Fei Wu, Jianyu Wang, Delin Wang, Zhenlin Zhao, Haihu Wu, Jiaju Lyu, Hao Ning

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical Medicine Insights. Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Feifan LiuDepartment of Urology, Shandong Provincial Hospital, Shandong University, Jinan, P.R. China.
Yufeng SongDepartment of Urology, Jinshan Hospital, Fudan University, Shanghai, P.R. China.
Fei WuDepartment of Urology, Shandong Provincial Hospital, Shandong University, Jinan, P.R. China.
Jianyu WangDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, P.R. China.
Delin WangDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, P.R. China.
Zhenlin ZhaoDepartment of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, P.R. China.
Haihu WuDepartment of Urology, Shandong Provincial Hospital, Shandong University, Jinan, P.R. China.
Jiaju LyuDepartment of Urology, Shandong Provincial Hospital, Shandong University, Jinan, P.R. China.
Hao NingDepartment of Urology, Shandong Provincial Hospital, Shandong University, Jinan, P.R. China.ORCID https://orcid.org/0009-0004-9609-9451

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The limitations of prostate-specific antigen (PSA) in diagnosing prostate cancer (PCa) necessitate the exploration of novel biomarkers. Recent studies suggest a potential link between coagulation markers, particularly fibrinogen and D-dimer, and PCa. Methods: A retrospective single-center analysis on 466 biopsy-undergone patients was conducted, categorized into PCa and benign prostatic hyperplasia (BPH) groups. Baseline and coagulation parameter levels were analyzed. Utilizing a Mendelian randomization (MR) approach, we investigated the causative relationship between D-dimer and PCa risk. Results: Individuals with PCa, compared with those with BPH, exhibited significantly higher D-dimer levels ( Conclusions: This research highlights D-dimer as a potential biomarker for diagnosing PCa, supported by clinical and MR analyses. The study paves the way for future large-scale, multi-center research to corroborate these findings and further explore the relationship between coagulation markers and PCa mechanisms.

Indexed as

biomarkercausalityD-dimerMendelian randomizationProstatic neoplasms

Identifiers

PMID39071532
PMCPMC11282561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.