ArticlebioRxiv : the preprint server for biology2024
Experimental evolution of gene essentiality in bacteria.
Liang Bao, Zan Zhu, Ahmed Ismail, Bin Zhu, Vysakh Anandan, Marvin Whiteley, Todd Kitten, Ping Xu
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Liang BaoDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.ORCID 0000-0002-0228-6124 Zan ZhuDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.
Ahmed IsmailDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.
Bin ZhuMassey Cancer Center, Virginia Commonwealth University, Virginia, USA.
Vysakh AnandanDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.
Marvin WhiteleySchool of Biological Sciences, Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Georgia, USA.
Todd KittenDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.ORCID 0000-0001-6097-7583 Ping XuDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Virginia, USA.ORCID 0000-0002-8368-801X Funding
Oral Streptococcal Fitness And Virulence genesR01DE030121 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI KITTEN, TODD O., XU, PING · 2021 to 2025
$2.5MComparative Experimental Evolution of Gene Essentiality in Streptococcus sanguinis and S. mutansR03DE034511 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI BAO, LIANG · 2025 to 2025
$311kNIDCR NIH HHS R01 DE030121NIDCR NIH HHS R03 DE034511
6 · The paper itselfAbstract
Essential gene products carry out fundamental cellular activities in interaction with other components. However, the lack of essential gene mutants and appropriate methodologies to link essential gene functions with their partners poses significant challenges. Here, we have generated deletion mutants in 32 genes previously identified as essential, with 23 mutants showing extremely slow growth in the SK36 strain of
Indexed as
Experimental evolutionF1Fo-ATPase/V1Vo-ATPase/TrkA1-H1 gene pathwayGene essentialitySpontaneous mutationsStreptococcusWhole-genome sequencing
Identifiers
PMID39071448
PMCPMC11275930
What OpenQuestion holds
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