Evidence map›Paper›PMID 39071435›Full record

ArticlebioRxiv : the preprint server for biology2025

Dynamical forces drive cell and organ morphology changes during embryonic development.

Raj Kumar Manna, Emma M Retzlaff, Anna Maria Hinman, Yiling Lan, Osama Abdel-Razek, Mike Bates, Heidi Hehnly, Jeffrey D Amack, M Lisa Manning

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Raj Kumar MannaDepartment of Physics Syracuse University, Syracuse, NY 13244, USA.ORCID 0000-0003-2272-9487
Emma M RetzlaffDepartment of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, NY, USA, 13210.ORCID 0000-0003-2589-4074
Anna Maria HinmanDepartment of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, NY, USA, 13210.
Yiling LanDepartment of Biology, Syracuse University, Syracuse, NY, USA.
Osama Abdel-RazekDepartment of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, NY, USA, 13210.ORCID 0000-0002-8450-4067
Mike BatesDepartment of Biology, Syracuse University, Syracuse, NY, USA.
Heidi HehnlyDepartment of Biology, Syracuse University, Syracuse, NY, USA.ORCID 0000-0001-6660-5254
Jeffrey D AmackDepartment of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, NY, USA, 13210.ORCID 0000-0002-5465-9754
M Lisa ManningDepartment of Physics Syracuse University, Syracuse, NY 13244, USA.ORCID 0000-0001-7682-2324

Funding

Four-dimensional prediction and quantification of how physical forces impact organogenesis in zebrafishR01HD099031 · NICHD · SYRACUSE UNIVERSITY · PI AMACK, JEFFREY D, MANNING, MARY ELIZABETH LISA · 2020 to 2024
$2.1M
The relationship between Rab11-endosomes and the centrosome during divisionR01GM127621 · NIGMS · SYRACUSE UNIVERSITY · PI HEHNLY, HEIDI · 2018 to 2022
$1.8M
Cell cycle dependent mechanisms triggering lumen formation in vivoR01GM130874 · NIGMS · SYRACUSE UNIVERSITY · PI HEHNLY, HEIDI · 2021 to 2024
$1.2M
NICHD NIH HHS R01 HD099031NIGMS NIH HHS R01 GM127621NIGMS NIH HHS R01 GM130874
6 · The paper itself

Abstract

Cells, tissues, and organs must change shape in precise ways during embryonic development to execute their functions. Multiple mechanisms including biochemical signaling pathways and biophysical forces help drive these morphology changes, but it has been difficult to tease apart their contributions, especially from tissue-scale dynamic forces that are typically ignored. We use a combination of mathematical models and

Identifiers

PMID39071435
PMCPMC11275717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.