Evidence map›Paper›PMID 39071432›Full record

ArticlebioRxiv : the preprint server for biology2025

Discovery of a Linked Constellation of Gene Expression Revealed by Local Editing of Fibroblasts in Tumors.

Nicholas F Kuhn, Itzia Zaleta-Linares, Kenneth H Hu, Tristan Courau, Brittany Davidson, Tammie Tam, Alexis J Combes, William A Nyberg, Justin Eyquem, Matthew F Krummel

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicholas F KuhnDepartment of Pathology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-5634-0846
Itzia Zaleta-LinaresDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Kenneth H HuDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Tristan CourauDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Brittany DavidsonDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Tammie TamDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Alexis J CombesDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
William A NybergDepartment of Medicine, University of California, San Francisco, CA, 94143, USA.ORCID 0000-0002-9982-1305
Justin EyquemBakar ImmunoX Initiative, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-8262-1190
Matthew F KrummelDepartment of Pathology, University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-7915-3533

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4M
The Tumor Microenvironment Niche of Type I conventional Dendritic CellsR01CA197363 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2017 to 2026
$4.5M
CONTROL OF T CELL SYNAPSE STABILIZATION AND SIGNALINGR37AI052116 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2023 to 2026
$2.5M
THE IMMUNE SELF-ASSOCIATED STORAGE ORGANELLE (SASO)R01AI175277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW F KRUMMEL · 2023 to 2026
$2.4M
Illumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583k
NCI NIH HHS R01 CA197363NCI NIH HHS T32 CA108462NIAID NIH HHS R01 AI175277NIAID NIH HHS R37 AI052116NIDDK NIH HHS P30 DK063720NIH HHS S10 OD028511
6 · The paper itself

Abstract

Fibroblasts play critical roles in regulating cellular relationships during tissue homeostasis, immunity, and tumor biology at multiple sites. However, tools to perturb fibroblasts at just one site in vivo are limited, restricting our understanding of how these cellular relationships develop on a local level. We optimized local gene editing of fibroblasts in multiple mouse tumor models to investigate how locally restricted fibroblast perturbations affect the cellular tumor microenvironment (TME). By knocking out surface receptors

Identifiers

PMID39071432
PMCPMC11275728

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.