Evidence map›Paper›PMID 39071393›Full record

ArticlebioRxiv : the preprint server for biology2024

Oral citrate supplementation mitigates age-associated pathological intervertebral disc calcification in LG/J mice.

Olivia K Ottone, Jorge J Mundo, Boahen N Kwakye, Amber Slaweski, John A Collins, Qinglin Wu, Margery A Connelly, Fatemeh Niaziorimi, Koen van de Wetering, Makarand V Risbud

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Olivia K OttoneDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Jorge J MundoDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Boahen N KwakyeDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Amber SlaweskiDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
John A CollinsDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Qinglin WuLabCorp, Morrisville, NC, USA.
Margery A ConnellyLabCorp, Morrisville, NC, USA.
Fatemeh NiaziorimiDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Koen van de WeteringDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Makarand V RisbudDepartment of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0003-3913-0649

Funding

Role of HIF-1 in Intervertebral Disc FunctionR01AR055655 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI RISBUD, MAKARAND V · 2008 to 2023
$6.1M
Disruption of Osmoregulation Promotes Degenerative Disc DiseaseR01AR064733 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI RISBUD, MAKARAND V, SHAPIRO, IRVING M · 2014 to 2018
$2.4M
Pathogenesis of Inflammation-driven Intervertebral Disc Herniation: The Role of Syndecan 4R01AR074813 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI RISBUD, MAKARAND V · 2019 to 2023
$2.3M
The role of endogenous low molecular weight mineralization inhibitors in spine healthR01AR082460 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI Makarand V Risbud, Koen van de Wetering · 2024 to 2026
$1.9M
NIAMS NIH HHS R01 AR055655NIAMS NIH HHS R01 AR064733NIAMS NIH HHS R01 AR074813NIAMS NIH HHS R01 AR082460
6 · The paper itself

Abstract

Despite the high prevalence of age-dependent intervertebral disc calcification, there is a glaring lack of treatment options for this debilitating pathology. Here, we investigate the efficacy of long-term oral K

Indexed as

agingcartilaginous endplatescitratedisc calcificationectopic calcificationintervertebral discLG/Jpotassium citrate

Identifiers

PMID39071393
PMCPMC11275755

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.