Evidence map›Paper›PMID 39071350›Full record

ArticlebioRxiv : the preprint server for biology2025

Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes.

Sherry Jingjing Wu, Min Dai, Shang-Po Yang, Cai McCann, Yanjie Qiu, Vipin Kumar, Giovanni J Marrero, Jeremiah Tsyporin, Shuhan Huang, David Shin and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Sherry Jingjing WuHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.ORCID 0000-0001-9625-1661
Min DaiHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.ORCID 0000-0001-7584-5014
Shang-Po YangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Cai McCannSpatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Yanjie QiuHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
Vipin KumarBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Giovanni J MarreroBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jeremiah TsyporinMolecular, Cell, and Developmental Biology Department, University of California, Santa Cruz, CA 95064.ORCID 0000-0001-6588-6840
Shuhan HuangHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.
David ShinBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jeffrey A StogsdillStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Daniela J Di BellaStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Qing XuCenter for Genomics & Systems Biology, New York University Abu Dhabi, Abu Dhabi, UAE.
Bin ChenMolecular, Cell, and Developmental Biology Department, University of California, Santa Cruz, CA 95064.
Samouil L FarhiSpatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-1359-4568
Evan Z MacoskoStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-2794-5165
Fei ChenBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-2308-3649
Gord FishellHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.ORCID 0000-0002-9640-9278

Funding

Comprehensive single-cell atlas of the developing mouse brainU01MH130962 · NIMH · HARVARD UNIVERSITY · PI Paola Arlotta, Tomasz Nowakowski · 2022 to 2026
$33.3M
Systematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortexUF1MH130701 · NIMH · BROAD INSTITUTE, INC. · PI ARLOTTA, PAOLA, DEVERMAN, BENJAMIN E · 2022 to 2022
$10.7M
Regional and Genetic Diversity of Cortical InterneuronsR01MH071679 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHELL, GORDON J · 2005 to 2020
$8.5M
The Development and Integration of Early Born SST-Expressing Interneurons in the CortexR01NS081297 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON J FISHELL · 2012 to 2026
$6.6M
The molecular and cellular basis of cortical interneuron divergenceR37MH071679 · NIMH · HARVARD MEDICAL SCHOOL · PI GORDON J FISHELL · 2022 to 2026
$4.1M
TissueCyte 1600FC Whole Mount Tissue ScannerS10OD026866 · OD · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2019 to 2019
$612k
Cortical interneuron subtypes adapt to signals from local pyramidal cellsF32MH125464 · NIMH · HARVARD MEDICAL SCHOOL · PI WU, JINGJING · 2021 to 2023
$224k
NIH HHS S10 OD026866NIMH NIH HHS F32 MH125464NIMH NIH HHS R01 MH071679NIMH NIH HHS R37 MH071679NIMH NIH HHS U01 MH130962NINDS NIH HHS R01 NS081297
6 · The paper itself

Abstract

The mammalian cerebral cortex comprises a complex neuronal network that maintains a precise balance between excitatory pyramidal neurons and inhibitory interneurons. Accumulating evidence indicates that specific interneuron subtypes form stereotyped microcircuits with distinct pyramidal neuron classes. Here we show that pyramidal neurons play an active role in this process by promoting the survival and terminal differentiation of their associated interneuron subtypes. In wild-type cortex, interneuron subtype abundance mirrors the prevalence of their pyramidal neuron partners. In

Identifiers

PMID39071350
PMCPMC11275907

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.