Evidence map›Paper›PMID 39071291›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies.

Sander Frank, Thomas Persse, Ilsa Coleman, Armand Bankhead, Dapei Li, Navonil De-Sarkar, Divin Wilson, Dmytro Rudoy, Manasvita Vashisth, Patty Galipeau and 11 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Sander FrankDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Thomas PersseDivison of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Ilsa ColemanDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Armand BankheadDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Dapei LiDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Navonil De-SarkarDepartment of Pathology, Medical College of Wisconsin, Milwaukee, WI, 53226.
Divin WilsonDepartment of Pathology, Medical College of Wisconsin, Milwaukee, WI, 53226.
Dmytro RudoyDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Manasvita VashisthDivison of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Patty GalipeauDivison of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Michael YangDivison of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Brian HanrattyDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Ruth DumpitDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Colm MorrisseyDepartment of Urology, University of Washington, Seattle, WA 98195.
Eva CoreyDepartment of Urology, University of Washington, Seattle, WA 98195.
R Bruce MontgomeryDepartment of Medicine, University of Washington, Seattle, WA 98195.
Michael C HaffnerDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Colin C PritchardDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195.
Valeri VasioukhinDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98119.
Gavin HaDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98119.ORCID 0000-0001-7578-7272
Peter S NelsonDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA 98119.ORCID 0000-0002-5451-5726

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
TRANSCRIPTOME AND PROTEOME STRATIFICATION OF PROSTATE ADENOCARCINOMA PHENOTYPESP50CA097186 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETER S NELSON · 2002 to 2026
$58.1M
Steroid Metabolism in Castration-Resistant Prostate CancerP01CA163227 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MYLES A BROWN · 2013 to 2026
$25.0M
Translating the tumor regulome from cell-free DNA for precision oncologyDP2CA280624 · NCI · FRED HUTCHINSON CANCER CENTER · PI HA, GAVIN · 2022 to 2025
$2.8M
Evaluating prostate cancer phenotype and genotype classification from circulating tumor DNA as biomarkers for predicting treatment outcomesR01CA280056 · NCI · FRED HUTCHINSON CANCER CENTER · PI Gavin Ha, PETER S NELSON · 2023 to 2026
$2.4M
Research Specialist in Cancer Genomics to Integrate Basic Research and Clinical DataR50CA274336 · NCI · FRED HUTCHINSON CANCER CENTER · PI ILSA COLEMAN · 2023 to 2026
$452k
A Prostate Cancer Dependency Map to Identify Tumor Subtype-Specific VulnerabilitiesR21CA277368 · NCI · FRED HUTCHINSON CANCER CENTER · PI NELSON, PETER S · 2023 to 2024
$442k
Investigating the Role of DNA Repair Mutations in Prostate Cancer Initiation, Progression, and Susceptibility to Targeted TherapiesF32CA243286 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI FRANK, SANDER BARKLEY · 2019 to 2021
$212k
NCI NIH HHS DP2 CA280624NCI NIH HHS F32 CA243286NCI NIH HHS P01 CA163227NCI NIH HHS P30 CA015704NCI NIH HHS P50 CA097186NCI NIH HHS R01 CA280056NCI NIH HHS R21 CA277368NCI NIH HHS R50 CA274336
6 · The paper itself

Abstract

Genomic loss of the transcriptional kinase

Indexed as

CDK12DNA repairPARPprostate cancertandem duplicationtherapeuticstranscription

Identifiers

PMID39071291
PMCPMC11275783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.