Evidence map›Paper›PMID 39071041›Full record

ArticleMacromolecules2024

Tuning Structural Organization via Molecular Design and Hierarchical Assembly to Develop Supramolecular Thermoresponsive Hydrogels.

Dan Jing Wu, Martin G T A Rutten, Jingyi Huang, Maaike J G Schotman, Johnick F van Sprang, Bart M Tiemeijer, Gijs M Ter Huurne, Sjors P W Wijnands, Mani Diba, Patricia Y W Dankers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dan Jing WuLaboratory for Cell and Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, PO Box 513 ,Eindhoven MB 5600, The Netherlands.
Martin G T A RuttenInstitute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513 ,Eindhoven MB 5600, The Netherlands.ORCID https://orcid.org/0000-0002-9846-4334
Jingyi HuangLaboratory for Cell and Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, PO Box 513 ,Eindhoven MB 5600, The Netherlands.
Maaike J G SchotmanInstitute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513 ,Eindhoven MB 5600, The Netherlands.
Johnick F van SprangLaboratory for Cell and Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, PO Box 513 ,Eindhoven MB 5600, The Netherlands.
Bart M TiemeijerInstitute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513 ,Eindhoven MB 5600, The Netherlands.
Gijs M Ter HuurneInstitute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513 ,Eindhoven MB 5600, The Netherlands.
Sjors P W WijnandsInstitute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513 ,Eindhoven MB 5600, The Netherlands.
Mani DibaInstitute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513 ,Eindhoven MB 5600, The Netherlands.
Patricia Y W DankersLaboratory for Cell and Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, PO Box 513 ,Eindhoven MB 5600, The Netherlands.ORCID https://orcid.org/0000-0002-8997-181X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cellular microenvironment is composed of a dynamic hierarchical fibrillar architecture providing a variety of physical and bioactive signals to the surrounding cells. This dynamicity, although common in biology, is a challenge to control in synthetic matrices. Here, responsive synthetic supramolecular monomers were designed that are able to assemble into hierarchical fibrous structures, combining supramolecular fiber formation via hydrogen bonding interactions, with a temperature-responsive hydrophobic collapse, resulting in cross-linking and hydrogel formation. Therefore, amphiphilic molecules were synthesized, composed of a hydrogen bonding ureido-pyrimidinone (UPy) unit, a hydrophobic alkyl spacer, and a hydrophilic oligo(ethylene glycol) tail. The temperature responsive behavior was introduced by functionalizing these supramolecular amphiphiles with a relatively short poly(

Identifiers

PMID39071041
PMCPMC11270986

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.