QUANTITATIVE BIOMARKERS REPRODUCIBILITY USING GENERATIVE ADVERSARIAL APPROACHES IN REDUCED TO CONVENTIONAL DOSE CT.

In recent years, several techniques for image-to-image translation by means of generative adversarial neural networks (GAN) have been proposed to learn mapping characteristics between a source and a target domain. In particular, in the medical imaging field conditional GAN frameworks with paired samples (cGAN) and unconditional cycle-consistent GANs with unpaired data (CycleGAN) have been demonstrated as a powerful scheme to model non-linear mappings that produce realistic target images from different modality sources. When proposing the usage and adaptation of these frameworks for medical image synthesis, quantitative and qualitative validation are usually performed by assessing the similarity between synthetic and target images in terms of metrics such as mean absolute error (MAE) or structural similarity (SSIM) index. However, an evaluation of clinically relevant markers showing that diagnostic information is not overlooked in the translation process is often missing. In this work, we aim at demonstrating the importance of validating medical image-to-image translation techniques by assessing their effect on the measurement of clinically relevant metrics and biomarkers. We implemented both a conditional and an unconditional approach to synthesize conventional dose chest CT scans from reduced dose CT and show that while both visually and in terms of traditional metrics the network appears to successfully minimize perceptual discrepancies, these methods are not reliable to systematically reproduce quantitative measurements of various chest biomarkers.