Evidence map›Paper›PMID 39070782›Full record

ArticleFrontiers in pharmacology2024

Investigation of immunomodulatory and cytotoxic effects of shed snake skin (

Cagri Caglar Sinmez, Emre Tüfekçi, Büşra Şeniz Demir, Ahmet Eken, Vehbi Guneş, Seda Ekici, Esra Bozkaya, Ali İlteriş Aykun

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Synthesizing hybrid copper phosphate (CuJournal of biological engineering · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cagri Caglar SinmezDepartment of History of Veterinary Medicine and Deontology, Faculty of Veterinary Medicine, Ziya Eren Drug Research and Application Center (ERFARMA), Erciyes University, Kayseri, Türkiye.
Emre TüfekçiDepartment of Internal Medicine, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Türkiye.
Büşra Şeniz DemirDepartment of Medical Biology, School of Medicine, Betül-Ziya Eren Genome and Stem Cell Center (GENKÖK), Erciyes University, Kayseri, Türkiye.
Ahmet EkenDepartment of Medical Biology, School of Medicine, Betül-Ziya Eren Genome and Stem Cell Center (GENKÖK), Erciyes University, Kayseri, Türkiye.
Vehbi GuneşDepartment of Internal Medicine, Faculty of Veterinary Medicine, Experimental Research and Application Center (DEKAM), Kayseri, Türkiye.
Seda EkiciVeterinary Control Central Research Institute, Ankara, Türkiye.
Esra BozkayaScientific and Technological Research Application and Research Center, Kırıkkale University, Kırıkkale, Türkiye.
Ali İlteriş AykunDepartment of History of Veterinary Medicine and Deontology, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Shed snake skin (SSS) is commonly used empirically in ethnomedicine to treat psoriasis, acne, warts, eczema, scabies, open wounds, hemorrhoids, and glaucoma. Although a few studies exist, SSS extracts' Methods: Hexane, methanol, and chloroform extractions were conducted in collected SSS samples. Protein concentrations in the SSS extract were measured. The cytotoxic and anticancer activities were measured using L929 Fibroblast and SK MEL 30 Cell Lines via MTT assay as described in TS EN ISO 10993-5. Immunomodulatory activities of SSS extract on total lymphocytes or enriched CD4 Results: Hexane, methanol, and chloroform-extracted SSS were tested on SK-MEL-30 cells via MTT and revealed a superior anti-proliferative effect for hexane extract of SSS at low concentrations. SSS treatment of murine lymphocytes augmented Tnf-α and IFN-γ levels produced by CD3 Discussion: This is the first

Indexed as

immunityimmunomodulationpro-inflammatory cytokinesShed snake skinT lymphocytes

Identifiers

PMID39070782
PMCPMC11272602

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.