Evidence map›Paper›PMID 39070663›Full record

ArticleAutophagy reports2024

A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during

Zachary D Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M Fielder, Jessie R Zhang, Hieu Hoang, David H Perlmutter, Cliff J Luke and 2 more

Abstract read
In one paragraph

Article in Autophagy reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zachary D DawsonDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.
Hemalatha SundaramoorthiDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.
Suk RegmiDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.
Bo ZhangDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.
Stephanie MorrisonDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.
Sara M FielderDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.
Jessie R ZhangDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.
Hieu HoangDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.
David H PerlmutterDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.
Cliff J LukeDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.
Gary A SilvermanDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.
Stephen C PakDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA.

Funding

Treating AT Deficiency with Drugs that Modulate the Proteostasis NetworkP01DK096990 · NIDDK · WASHINGTON UNIVERSITY · PI FOX, IRA J. · 2012 to 2023
$18.3M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Inhibitors of Intestinal Epithelial Cell Lysosomal-Mediated NecrosisR01DK114047 · NIDDK · WASHINGTON UNIVERSITY · PI LUKE, CLIFFORD JAMES, SILVERMAN, GARY ARTHUR · 2018 to 2021
$1.7M
Genetic Modifiers Affecting Cellular Injury in Alpha-1-Antitrypsin DeficiencyR01DK104946 · NIDDK · WASHINGTON UNIVERSITY · PI SILVERMAN, GARY ARTHUR · 2016 to 2019
$1.4M
NIDDK NIH HHS P01 DK096990NIDDK NIH HHS R01 DK104946NIDDK NIH HHS R01 DK114047NIH HHS P40 OD010440
6 · The paper itself

Abstract

Autophagy is important for many physiological processes; and disordered autophagy can contribute to the pathogenesis of a broad range of systemic disorders.

Indexed as

Biomarkerhigh-content screeningLC3LGG-1probesmall molecule

Identifiers

PMID39070663
PMCPMC11271720

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.