Evidence map›Paper›PMID 39070161›Full record

ArticleFrontiers in bioengineering and biotechnology2024

Silicone rubber membrane devices permit islet culture at high density without adverse effects.

Efstathios S Avgoustiniatos, Kate R Mueller, William E Scott Iii, Jennifer P Kitzmann, Thomas M Suszynski, Brian E Perrault, Eric J Falde, A N Balamurugan, Bernhard J Hering, Charles W Putnam and 1 more

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Article in Frontiers in bioengineering and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Efstathios S AvgoustiniatosDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Kate R MuellerDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
William E Scott IiiDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Jennifer P KitzmannDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Thomas M SuszynskiDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Brian E PerraultDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Eric J FaldeDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
A N BalamuruganDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Bernhard J HeringDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.
Charles W PutnamDepartment of Surgery, Institute for Cellular Transplantation, University of Arizona, Tucson, AZ, United States.
Klearchos K PapasDepartment of Surgery, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Conventional culture conditions, such as in T-flasks, require that oxygen diffuse through the medium to reach the islets; in turn, islet surface area density is limited by oxygen availability. To culture a typical clinical islet preparation may require more than 20 T-175 flasks at the standard surface area density of 200 IE/cm Methods: Oxygenation of individual islets under three culture conditions, standard low-density, Results: In simulations, individual islets under standard culture conditions and high density cultures on GP membranes were both well oxygenated whereas Discussion: Culturing islets in GP devices allows for a 20-fold increase of islet surface area density, greatly simplifying the culture process while maintaining islet viability and metabolism.

Indexed as

gas-porous membraneG-Rexhigh-density islet cultureislet oxygenationislet recoveryislet viabilityoxygenation modelsilicone rubber membrane

Identifiers

PMID39070161
PMCPMC11273363

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.