ReviewToxicology reports2024
Zearalenone, an estrogenic component, in bovine milk, amount and detection method; A systematic review and meta-analysis.
Review in Toxicology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Multi-mycotoxin biomonitoring in Italian adults: Revealing the connection between diet habits and mycotoxin exposure.Environment international · 2026Article
- Article
- Overview of recent advances in zearalenone (ZEN) research.EXCLI journal · 2026Review
- Nutritional Impact on Breast Cancer in Menopausal and Post-Menopausal Patients Treated with Aromatase Inhibitors.Cancers · 2025Review
- Health Risk Assessment of Dietary Chemical Exposures: A Comprehensive Review.Foods (Basel, Switzerland) · 2025Review
- Research Progress on the Application of Nanoenzyme Electrochemical Sensors for Detecting Zearalenone in Food.Nanomaterials (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zearalenone (ZEN) and its metabolites are a potent component with estrogenic potential that can enter milk. ZEN and its metabolites have the ability to disturb the function of endocrine glands. The aim of this systematic review was to estimate the level of ZEN and its metabolites in milk. This study was performed with these keywords; zearalenone, ZEN, bovine milk, ruminant milk, milk, dairy products, and milk product in various databases. 946 manuscripts were collected from databases and at the end, 17 manuscripts were reviewed according to the inclusion criteria. ZEN was identified in 59 % of studies. The most common methods of analysis were UHPLC, HPLC and ELISA. Meta-analysis was performed with CMA (Comprehensive Meta-Analysis) software. No publication bias was observed in meta- analysis. But, heterogeneity was recorded between studies. The measurement method was identified as one of the sources of heterogeneity through meta-regression tests and subgroup analysis. Furthermore, in meta- analysis test, the total estimate of milk contamination with this mycotoxin was 0.036±0.017 µg/L. So far, the permissible limit for this compound in milk has not been announced, but these compounds have the ability to disturb the endocrine glands in low amounts. Therefore, it is necessary to regularly measure and control this mycotoxin and its metabolite in milk with valid methods.
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