Evidence map›Paper›PMID 39069829›Full record

ReviewAmerican journal of physiology. Cell physiology2024

Skeletal muscle hypertrophy: cell growth is cell growth.

Benjamin I Burke, Ahmed Ismaeel, Ferdinand von Walden, Kevin A Murach, John J McCarthy

Abstract readReview
In one paragraph

Review in American journal of physiology. Cell physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Biomaterials science · 2025
    Review
  5. Review
  6. Review
  7. From gains to liver pain: when exercise training goes too far.Extracellular vesicles and circulating nucleic acids · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Benjamin I BurkeDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.ORCID 0000-0003-0228-1750
Ahmed IsmaeelDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.ORCID 0000-0003-4025-3945
Ferdinand von WaldenDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.ORCID 0000-0003-1134-2252
Kevin A MurachDepartment Health, Human Performance, and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0003-2783-7137
John J McCarthyDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States.ORCID 0000-0003-4522-5601

Funding

Mediators of Muscle Rejuvenation with AgingR01AG080047 · NIA · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI Kevin Murach · 2023 to 2026
$2.3M
The role of satellite cells in skeletal muscle hypertrophy with agingR01AG069909 · NIA · UNIVERSITY OF KENTUCKY · PI MCCARTHY, JOHN JOSEPH, WEN, YUAN · 2021 to 2025
$2.1M
The effects of exercise on satellite cell dynamics during agingR01AG049806 · NIA · UNIVERSITY OF KENTUCKY · PI MCCARTHY, JOHN JOSEPH, PETERSON, CHARLOTTE A. · 2016 to 2020
$1.8M
HHS | NIH | National Institute on Aging (NIA) R01AG069909HHS | NIH | National Institute on Aging (NIA) R01AG080047NIA NIH HHS R01 AG049806NIA NIH HHS R01 AG069909NIA NIH HHS R01 AG080047Swedish Research Council 2022-01392Swedish Research Council for Sport Science 2022/10, 2023/09
6 · The paper itself

Abstract

Roberts et al. have provided an insightful counterpoint to our review article on the utility of the synergist ablation model. The purpose of this review is to provide some further dialogue regarding the strengths and weaknesses of the synergist ablation model. Specifically, we highlight that the robustness of the model overshadows surgical limitations. We also compare the transcriptomic responses to synergist ablation in mice and resistance exercise in humans to identify common pathways. We conclude that "cell growth is cell growth" and that the mechanisms available to cells to accumulate biomass and increase in size are similar across cell types and independent of the rate of growth.

Indexed as

Cell ProliferationHypertrophyMuscle, SkeletalAnimalsHumansMicehypertrophymuscleresistance trainingsynergist ablation

Identifiers

PMID39069829
PMCPMC11901336

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.