Evidence map›Paper›PMID 39069707›Full record

ReviewCurrent cancer drug targets2025

A Comprehensive Review on Novel Pathways in Cancer Treatment: Clinical Applications and Future Prospects.

A S Shifana, Mohammad Adnan, Akash Gupta, Ajazuddin, Parag Jain

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cancer drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A S ShifanaDepartment of Pharmacology, Rungta College of Pharmaceutical Science and Research, Bhilai, Chhattisgarh, India.
Mohammad AdnanDepartment of Pharmacology, Rungta College of Pharmaceutical Science and Research, Bhilai, Chhattisgarh, India.
Akash GuptaDepartment of Pharmacology, Rungta College of Pharmaceutical Science and Research, Bhilai, Chhattisgarh, India.
AjazuddinDepartment of Pharmacology, Rungta College of Pharmaceutical Science and Research, Bhilai, Chhattisgarh, India.
Parag JainDepartment of Pharmacology, Rungta College of Pharmaceutical Science and Research, Bhilai, Chhattisgarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a global health issue that requires ongoing therapeutic advances. This review provides an overview of recent treatment strategies focusing on novel pathways in cancer therapy. Emerging research has unveiled promising targets that go beyond traditional modalities, offering new avenues for precision medicine and improved patient outcomes. One key area of innovation lies in targeted therapies directed at specific molecular pathways implicated in cancer progression. The identification of novel biomarkers has paved the way for the development of precision medicines tailored to individual patient profiles. Immunotherapy has also revolutionised cancer treatment by using the immune system to identify and remove cancer cells. Moreover, advancements in epigenetic therapies and RNA-based interventions demonstrate unprecedented potential in modulating gene expression and disrupting cancer-specific signalling pathways. We have discussed the pathophysiology of cancer, different immune checkpoint inhibitors, and targeted therapies in signalling therapies. The epigenetic modulators, such as Histone deacetylase (HDACs) inhibitors and DNA methyltransferase (DNMT) inhibitors, were studied. Recent breakthroughs in cancer immunotherapy treatment (CAR-T) cell therapy showcase the potential to enhance the immune response against various cancers; thus, related information was incorporated. RNA-based therapies like RNA interference and mRNA-based vaccines and therapies, combination therapies, and novel therapies were discussed in the present article.

Indexed as

NeoplasmsAnimalsEpigenesis, GeneticHumansImmune Checkpoint InhibitorsImmunotherapyMolecular Targeted TherapyPrecision MedicineSignal TransductionImmune Checkpoint InhibitorsCancer treatmentemerging biomarkersimmunotherapy.novel pathwaysprecision medicinetargeted therapies

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.