Evidence map›Paper›PMID 39069692›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2024

Neural Antibodies in First-episode Psychosis Patients with Warning Signs for Autoimmune Encephalitis.

Denis Pavăl, Nicoleta Gherghel-Pavăl, Octavia Oana Căpățînă, Adina Stan, Lajos Raduly, Liviuța Budișan, Ioana Valentina Micluția

Abstract read
In one paragraph

Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Early psychiatric manifestations in pediatric autoimmune encephalitis: clinical data from a tertiary center.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Observational
  4. Autoimmune neuropsychiatric disorders manifesting with psychosis.The Journal of clinical investigation · 2025
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Denis PavălDepartment of Psychiatry, Iuliu Ha?ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.ORCID https://orcid.org/0000-0003-0532-586X
Nicoleta Gherghel-PavălRomanian Association for Autoimmune Encephalitis, Cluj-Napoca, Romania.ORCID https://orcid.org/0000-0001-7205-628X
Octavia Oana CăpățînăDepartment of Psychiatry, Iuliu Ha?ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.ORCID https://orcid.org/0000-0003-4967-8165
Adina StanDepartment of Neurology, Iuliu Ha?ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.ORCID https://orcid.org/0000-0001-8856-4078
Lajos RadulyResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Ha?ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.ORCID https://orcid.org/0000-0002-3926-5423
Liviuța BudișanResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Ha?ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.ORCID https://orcid.org/0000-0001-5725-662X
Ioana Valentina MicluțiaDepartment of Psychiatry, Iuliu Ha?ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.ORCID https://orcid.org/0000-0003-2478-0876

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: : Autoimmune encephalitis (AE) remains an essential differential diagnosis in patients with first-episode psychosis (FEP). In this study, we aimed to assess to prevalence of AE in a cohort of FEP patients. Methods: : We used a phenotype-driven algorithm to detect AE in patients with FEP. Initially, we screened patients for warning signs with a low or high pre-test probability for AE, defined as "yellow" and "red flags", respectively. In the next step, patients with red flags underwent cerebrospinal fluid analysis (including neural antibodies), while patients with yellow flags underwent tests for serum neural antibodies, electroencephalography, and brain magnetic resonance imaging. Results: : We screened 78 patients with FEP and found that eight (10.3%) had at least one warning sign for AE: four (5.13%) patients had at least one red flag, while four (5.13%) had only yellow flags. Among these, two patients (2.56%) had anti-N-methyl-D-aspartate receptor encephalitis, while the remaining six (7.69%) received a primary psychiatric disorder diagnosis. Conclusion: : Our study highlights the importance of considering AE in the differential diagnosis of FEP.

Indexed as

AlgorithmsAutoimmune encephalitisAutoimmune psychosisFirst-episode psychosisNeural antibodiesWarning signs

Identifiers

PMID39069692
PMCPMC11289598

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.