Evidence map›Paper›PMID 39069607›Full record

ArticleJournal of nanobiotechnology2024

A nanozyme-functionalized bilayer hydrogel scaffold for modulating the inflammatory microenvironment to promote osteochondral regeneration.

Chuan Hu, Ruipeng Huang, Jiechao Xia, Xianjing Hu, Dingqi Xie, Yang Jin, Weiming Qi, Chengliang Zhao, Zhijun Hu

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Chuan Hu *Department of Orthopaedic Surgery, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, 310016, China.
Ruipeng Huang *Department of Orthopaedic Surgery, the Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Jiechao Xia *Department of Orthopaedic Surgery, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, 310016, China.
Xianjing HuThe Second Affiliated Hospital of Wenzhou Medical University, Wenzhu, 325000, China.
Dingqi XieDepartment of Orthopaedic Surgery, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, 310016, China.
Yang JinDepartment of Orthopaedic Surgery, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, 310016, China.
Weiming QiZhejiang Center for Medical Device Evaluation, Zhejiang Medical Products Administration, Hangzhou, 310009, China. qwm3140@126.com.
Chengliang ZhaoDepartment of Orthopaedic Surgery, the Affiliated Hospital of Qingdao University, Qingdao, 266000, China. zhaochengliang@qdu.edu.cn.
Zhijun HuDepartment of Orthopaedic Surgery, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, 310016, China. hzjspine@zju.edu.cn.

Funding

Natural Science Foundation of Zhejiang Province of China LY22H060003
6 · The paper itself

Abstract

backgroundThe incidence of osteochondral defects caused by trauma, arthritis or tumours is increasing annually, but progress has not been made in terms of treatment methods. Due to the heterogeneous structure and biological characteristics of cartilage and subchondral bone, the integration of osteochondral repair is still a challenge.

resultsIn the present study, a novel bilayer hydrogel scaffold was designed based on anatomical characteristics to imitate superficial cartilage and subchondral bone. The scaffold showed favourable biocompatibility, and the addition of an antioxidant nanozyme (LiMn

conclusionsIn general, our biomimetic hydrogel scaffold with the ability to regulate the inflammatory microenvironment can effectively repair osteochondral defects. This strategy provides a promising method for regenerating tissues with heterogeneous structures and biological characteristics.

Indexed as

Bone RegenerationHydrogelsMesenchymal Stem CellsOsteogenesisRats, Sprague-DawleyTissue ScaffoldsAnimalsCartilageCartilage, ArticularCell DifferentiationCells, CulturedChondrocytesChondrogenesisInflammationMaleRatsHydrogelsReactive Oxygen SpeciesHydrogelInflammatory regulationNanozymeOsteochondral regeneration

Identifiers

PMID39069607
PMCPMC11283693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.