Evidence map›Paper›PMID 39069591›Full record

ReviewPediatric radiology2025

Abdominal imaging in precocious puberty in girls: can imaging determine onset of puberty?

Anne M Smets, Carmelo Sofia, Costanza Bruno, Damjana Ključevšek, Maria Luisa Lobo, Marcello Napolitano, H Nursun Ozcan, Samuel Stafrace, Philippe Petit, Lil-Sofie Ording Müller

Abstract readReview
In one paragraph

Review in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anne M SmetsDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. a.m.smets@amsterdamumc.nl.ORCID 0000-0003-0684-1436
Carmelo SofiaDepartment of Biomedical Sciences and Morphologic and Functional Imaging, University of Messina, Messina, Italy.ORCID 0000-0001-6021-4658
Costanza BrunoRadiology Department, AOUI Verona (Azienda Ospedaliera Universitaria Integrata), Verona, Italy.ORCID 0000-0002-9738-1457
Damjana KljučevšekDepartment of Radiology, University Children's Hospital Ljubljana, Ljubljana, Slovenia.ORCID 0000-0001-7075-2943
Maria Luisa LoboUnidade Local de Saúde de Santa Maria (ULSSM, Former CHULN), Av Professor Egas Moniz, 1649-028, Lisbon, Portugal.ORCID 0000-0002-4790-5494
Marcello NapolitanoDepartment of Pediatric Radiology and Neuroradiology, V. Buzzi Children's Hospital, Milan, Italy.ORCID 0000-0003-0288-3858
H Nursun OzcanDepartment of Radiology/Division of Pediatric Radiology, Hacettepe University School of Medicine, Ankara, Turkey.ORCID 0000-0003-4756-4359
Samuel StafraceMcMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-0056-5311
Philippe PetitDepartment of Pediatric Radiology, Hôpital Timone Enfants, Aix Marseille-Université, Marseille, France.ORCID 0000-0002-8395-0882
Lil-Sofie Ording MüllerDivision of Radiology and Nuclear Medicine, Department of Paediatric Radiology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-6529-4984

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precocious puberty in girls is defined by the appearance of secondary sex characteristics before the age of 8 years. Precocious puberty is either peripheral or central. In most cases, the cause of central precocious puberty is unknown. Rapidly progressive forms of central precocious puberty may benefit from puberty suppression to prevent compromised final height and psychosocial problems related to the physical changes. Idiopathic central precocious puberty in girls can be a challenging diagnosis. Clinical examination, evaluation of growth charts, bone age, and hormonal tests are part of the workup. The role of pelvic ultrasound to evaluate pubertal features of the internal genitalia in this context is controversial. In this paper, we have reviewed the literature to find the scientific bases for several proposed ultrasound parameters and cutoff values for the determination of onset of puberty in girls with suspected central precocious puberty. There are no reliable cutoffs for the measurements of uterus and ovaries for the diagnosis of central precocious puberty and there is overlap in the appearance of the organs in both prepubertal and pubertal girls. The interpretation of the findings on pelvic ultrasound must be done with caution and always in close communication with the referring clinicians.

Indexed as

AbdomenPuberty, PrecociousChildFemaleHumansUltrasonographyChildFemaleOvaryPrecociousPubertyUltrasoundUterus

Identifiers

PMID39069591
PMCPMC11982095

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.