Evidence map›Paper›PMID 39069559›Full record

ArticleScientific reports2024

Synthesis, α-glucosidase inhibitory activity, and molecular dynamic simulation of 6-chloro-2-methoxyacridine linked to triazole derivatives.

Mehdi Asadi, Mohammad Mehdi Ahangari, Aida Iraji, Homa Azizian, Ali Nokhbehzaim, Saeed Bahadorikhalili, Somaye Mojtabavi, Mohamad Ali Faramarzi, Ensieh Nasli-Esfahani, Bagher Larijani and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. α-Glucosidase Inhibitory Potential ofFood science & nutrition · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mehdi AsadiRazi Drug Research Center, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Mohammad Mehdi AhangariDepartment of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Aida IrajiStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Homa AzizianRazi Drug Research Center, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Ali NokhbehzaimDepartment of Medicinal Chemistry, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Islamic Republic of Iran.
Saeed BahadorikhaliliDepartment of Electronic Engineering, Universitat Rovira I Virgili, 43007, Tarragona, Spain.
Somaye MojtabaviDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Mohamad Ali FaramarziDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Ensieh Nasli-EsfahaniDiabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Bagher LarijaniEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Mohammad MahdaviEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. Mahdavi_chem@yahoo.com.
Massoud AmanlouDepartment of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. amanlou@tums.ac.ir.

Funding

Tehran University of Medical Sciences and Health Services 1402-2-104-67633
6 · The paper itself

Abstract

Α-glucosidase inhibition can be useful in the management of carbohydrate-related diseases, especially type 2 diabetes mellitus. Therefore, in this study, a new series of 6-chloro-2-methoxyacridine bearing different aryl triazole derivatives were designed, synthesized, and evaluated as potent α-glucosidase inhibitors. The most potent derivative in this group was 7h bearing para-fluorine with IC

Indexed as

Acridinesalpha-GlucosidasesGlycoside Hydrolase InhibitorsMolecular Dynamics SimulationTriazolesHumansKineticsMolecular Docking SimulationStructure-Activity RelationshipAcridinesalpha-GlucosidasesGlycoside Hydrolase InhibitorsTriazolesAcridineMolecular dynamic simulationSynthesisTriazoleα-Glucosidase

Identifiers

PMID39069559
PMCPMC11284203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.