ArticleTranslational psychiatry2024
Developing a phenotype risk score for tic disorders in a large, clinical biobank.
Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Persistent tic disorders are associated with 17q12 duplications.Molecular psychiatry · 2026Article
- Developing a phenotype risk score formedRxiv : the preprint server for health sciences · 2026Article
- Investigating the pharmaceutical substances and action mechanisms of Changmaxifeng granules against tic disorders.World journal of psychiatry · 2025Article
- Identification of Transdiagnostic Childhood Externalizing Pathology Within an Electronic Medical Records Database and Application to the Analysis of Rare Copy Number Variation.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
- Optimization of self- or parent-reported psychiatric phenotypes in longitudinal studies.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
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Abstract
Tics are a common feature of early-onset neurodevelopmental disorders, characterized by involuntary and repetitive movements or sounds. Despite affecting up to 2% of children and having a genetic contribution, the underlying causes remain poorly understood. In this study, we leverage dense phenotype information to identify features (i.e., symptoms and comorbid diagnoses) of tic disorders within the context of a clinical biobank. Using de-identified electronic health records (EHRs), we identified individuals with tic disorder diagnosis codes. We performed a phenome-wide association study (PheWAS) to identify the EHR features enriched in tic cases versus controls (n = 1406 and 7030; respectively) and found highly comorbid neuropsychiatric phenotypes, including: obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorder, and anxiety (p < 7.396 × 10
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