Evidence map›Paper›PMID 39068878›Full record

ArticleSchizophrenia research2024

Early cognitive development and psychopathology in children at familial high risk for schizophrenia.

Rebecca L Stephens, Isabel Leavitt, Emil Cornea, L Fredrik Jarskog, John H Gilmore

Abstract read
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In one paragraph

Article in Schizophrenia research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Rebecca L StephensDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Isabel LeavittDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Emil CorneaDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
L Fredrik JarskogDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
John H GilmoreDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. Electronic address: jgilmore@med.unc.edu.

Funding

Prospective study of the onset of schizophreniaP50MH064065 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2002 to 2011
$19.6M
Early Brain Development in TwinsR01MH070890 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2004 to 2014
$5.3M
Early Brain Development in One and Two Year OldsR01HD053000 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2007 to 2018
$4.4M
The Development of Individual Differences in Adolescent Brain Structure and RiskR01MH123747 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2021 to 2025
$3.8M
The Origins of Preadolescent Risk for Psychiatric Disorders in Early Childhood Brain DevelopmentR01MH111944 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GILMORE, JOHN HORACE · 2017 to 2021
$3.5M
NICHD NIH HHS R01 HD053000NIMH NIH HHS P50 MH064065NIMH NIH HHS R01 MH070890NIMH NIH HHS R01 MH111944NIMH NIH HHS R01 MH123747
6 · The paper itself

Abstract

Schizophrenia is a neurodevelopmental disorder associated with deficits in cognitive development and childhood psychopathology. Previous studies have focused on older children and the few studies of early childhood have yielded inconsistent findings. We studied cognitive development and psychopathology in children at familial high risk (FHR) of schizophrenia and matched controls from 1 to 6 years and hypothesized that FHR children would show consistent deficits across cognitive and behavioral measures in early childhood. STUDY

designCognitive development in children at high familial risk for schizophrenia or schizoaffective disorder (n = 33) and matched healthy controls (n = 66) was assessed at 1 and 2 years with the Mullen Scales of Early Learning, and at 4 and 6 years with the Stanford Binet Intelligence Scales, BRIEF-P/BRIEF and CANTAB. Psychopathology was assessed at 4 and 6 years with the BASC-2. General linear models were used to examine differences on outcome scores, and chi-square analyses were used to explore differences in the proportion of "at risk" or "below average" score profiles. STUDY

resultsFHR children scored significantly lower than controls on Mullen Composite at age 2, and demonstrated broad deficits in IQ, executive function and working memory and 4 and 6 years. FHR children were also rated as significantly worse on most items of the BASC-2 at ages 4 and 6.

conclusionsChildren at FHR for schizophrenia demonstrate abnormal cognitive development and psychopathology at younger ages than previously detected, suggesting that early detection and intervention needs to be targeted to very early childhood.

Indexed as

Child DevelopmentPsychotic DisordersSchizophreniaChildChild, PreschoolFemaleHumansInfantMaleNeuropsychological TestsRiskAnxietyAttentionExecutive functionExternalizing symptomsIntelligence

Identifiers

PMID39068878
PMCPMC11384306

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.