Evidence map›Paper›PMID 39068569›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2024

Nutritional Status and Body Composition at Diagnosis, of South Indian Children with Acute Lymphoblastic Leukaemia (ALL).

Deepa Puttaswamy, Vaishnavi Ramesh, Tony Raj, Kishor G Bhat, Sumithra Selvam, Vandana Bharadwaj, Anand Prakash, Alexia J Murphy-Alford, Rebecca Kuriyan

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Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

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0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Deepa PuttaswamyDivision of Nutrition, St. John's Research Institute St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India.
Vaishnavi RameshDivision of Nutrition, St. John's Research Institute St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India.
Tony RajDivision of Medical Informatics, St. John's Research Institute, St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India.
Kishor G BhatDivision of Nutrition, St. John's Research Institute St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India.
Sumithra SelvamDivision of, Epidemiology, Biostatistics and Population Health, St. John's Research Institute, St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India.ORCID 0000-0003-3229-267X
Vandana BharadwajDepartment of Pediatric Oncology, St. John's Medical College Hospital, St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India.
Anand PrakashDepartment of Pediatric Oncology, St. John's Medical College Hospital, St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India.
Alexia J Murphy-AlfordDepartment of Nuclear Sciences and Applications, International Atomic Energy Agency (IAEA), Vienna, Austria.
Rebecca KuriyanDivision of Nutrition, St. John's Research Institute St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India.ORCID 0000-0002-3864-574X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate estimation of body composition, particularly, Body Cell Mass (BCM), which is independent of hydration status is important in children with cancer. This study aimed to accurately measure the anthropometry and body composition of children with Acute Lymphoblastic Leukaemia (ALL) at diagnosis and compare them with healthy children from South India.

methodsThis was a cross-sectional study in children aged 2 to 8 y with ALL from St. John's Medical College Hospital, Bengaluru, and age and sex-matched, normal-weight children recruited as controls from communities. Anthropometry (weight, height, circumferences), skinfolds and body composition measurements using a whole-body potassium counter were performed. Body mass index-for-age, weight and height for age z-scores were calculated using WHO child growth standards. Biochemical markers, dietary intake and physical activity details were recorded. Categorical and continuous variables were analyzed by chi-square and independent t-tests respectively.     Results: The mean age of the children with ALL (n = 39) was 4.6±1.9 y and control group (n=39) was 4.7±1.9 y; 61.5% were boys. The prevalence of underweight, overweight/obesity and stunting were 17.9%, 7.7%, and 10.3% respectively. The mean weight and height, of children with ALL and children in the control group were 16.8±6.2 kg and 16.4±4.1 kg, 104.3±14.9 cm and 105.1±12.2 cm, respectively with no statistical difference. Children with ALL showed lower body cell mass index kg/m2 (4.6± 0.8), compared to children in the control group (4.7±0.9) p=0.527, but higher fat mass index kg/m2 (3.6±1.1 vs. 3.4±0.8) p=0.276.

conclusionAt diagnosis, anthropometric and body composition measurements were similar between children with ALL and children in the control group. The BCM showed a non-significant trend of being lower in children with ALL, which requires close monitoring during treatment. Evaluating early-stage nutritional status and body composition can help in planning appropriate interventions during treatment to prevent long term non-communicable diseases.

Indexed as

Body CompositionBody Mass IndexNutritional StatusPrecursor Cell Lymphoblastic Leukemia-LymphomaBody WeightCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesFemaleFollow-Up StudiesHumansIndiaMaleOverweightPrognosisbody cell massbody compositionbody fatchildrenLeukemia

Identifiers

PMID39068569
PMCPMC11480615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.