ArticleEuropean journal of medical research2024
Association between different triglyceride-glucose index combinations with obesity indicators and arthritis: results from two nationally representative population-based study.
Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Population-specific association and risk discrimination utility of the cardiometabolic index for prevalent hypertension-diabetes comorbidity: insights from CHARLS and NHANES.Clinical and experimental medicine · 2026Article
- Association between estimated cardiorespiratory fitness and arthritis in older adults: evidence from four large cohorts.Clinical rheumatology · 2026Article
- Article
- Global burden of early-onset colorectal cancer related to alcohol, tobacco, and physical inactivity: evidence from the global burden of disease 2021.Frontiers in oncology · 2026Article
- Prognostic value of the triglyceride-glucose index for ICU mortality in non-diabetic sepsis: a restricted cubic spline analysis.Frontiers in endocrinology · 2026Article
- Assessing the role of the Triglyceride-glucose related indices in identifying metabolic syndrome risk across body mass index categories.Endocrine · 2025Article
- Association between Osteoarthritis and the Triglyceride-Glucose Index in the Korean Population: A Large-Scale Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Progress in Prognostic Metabolic Biomarkers for Coronary Artery Disease Patients Post-Percutaneous Coronary Intervention.Reviews in cardiovascular medicine · 2025Review
- Association of eight anthropometric indexes related to obesity with the prevalence of clinical osteoarthritis among American adults: a national cross-sectional study.European journal of medical research · 2025Article
- Triglyceride-glucose-waist circumference index: A powerful tool for metabolic dysfunction-associated steatotic liver disease.World journal of hepatology · 2025Review
- Association between the triglyceride-glucose-waist-to-height ratio and early arterial stiffness in cardiovascular-kidney-metabolic syndrome.European journal of medical research · 2025Article
- Vitamin E intake mediates the associations of triglyceride-glucose index and its related parameters with phenotypic age acceleration in middle-aged and elderly population.Scientific reports · 2025Article
- The value of triglyceride-glucose index-related indices in evaluating migraine: perspectives from multi-centre cross-sectional studies and machine learning models.Lipids in health and disease · 2025Article
- Association between atherogenic index of plasma with all-cause and cardiovascular mortality in individuals with Cardiovascular-Kidney-Metabolic syndrome.Cardiovascular diabetology · 2025Article
- Association between triglyceride glucose-body mass index and the trajectory of cardio-renal-metabolic multimorbidity: insights from multi-state modelling.Cardiovascular diabetology · 2025Article
- Development and validation of a nomogram for arthritis: a cross-sectional study based on the NHANES.Scientific reports · 2025Article
- The association of triglyceride-glucose and triglyceride-glucose related indices with the risk of heart disease in a national.Cardiovascular diabetology · 2025Article
- Associations between surrogate insulin resistance indexes and osteoarthritis: NHANES 2003-2016.Scientific reports · 2025Article
- The role of triglycerides in predicting new-onset arthritis in the general population over 45 years old: evidence from the China health and retirement longitudinal study.Frontiers in endocrinology · 2025Article
- Relationship Between Triglyceride-Glucose Index and Handgrip Strength in the Midlife and Elderly Population: Evidence From a Chinese Cohort.International journal of endocrinology · 2025Article
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Funding
Abstract
backgroundInsulin resistance (IR) and arthritis are strongly associated, and the triglyceride-glucose (TyG) index combinations with obesity indicators [including TyG-BMI (glucose triglyceride-body mass index), TyG-WC (glucose triglyceride-waist circumference), and TyG-WHtR (glucose triglyceride-waist height ratio)] has recently been recognized as a more effective indicator for assessing IR. However, there is a lack of research on its association with arthritis, and it is also important to assess in different populations.
methodsThe analysis utilized data from the China Health and Retirement Longitudinal Study (CHARLS) and the National Health and Nutrition Examination Survey (NHANES). Arthritis diagnosis relied on self-reporting confirmed by physicians. The association of TyG-BMI, TyG-WC, and TyG-WHtR with arthritis was analyzed through weighted logistic regression models, and exploring nonlinear effects with restricted cubic spline (RCS) models. Secondary and sensitivity analyses included receiver operating characteristic curve (ROC) analysis, comparisons of z score-related odds ratios, subgroup analyses, and multiple imputation.
resultsThe study involved 6141 CHARLS participants and 17,091 NHANES participants. Adjusting for confounding variables, TyG-BMI and TyG-WHtR demonstrate a positive correlation with arthritis prevalence in both CHARLS (TyG-BMI: OR = 1.02, 95% CI 1.00-1.04; TyG-WHtR: OR = 1.13, 95% CI 1.03-1.24) and NHANES (TyG-BMI: OR = 1.07, 95% CI 1.06-1.08; TyG-WHtR: OR = 1.50, 95% CI 1.40-1.60). RCS regression analysis demonstrated a significant nonlinear association. ROC analysis indicated that TyG-BMI and TyG-WHtR were superior to TyG for the diagnosis of arthritis in both CHARLS and NHANES.
conclusionsTyG-BMI and TyG-WHtR demonstrate a positive correlation with arthritis prevalence in both Chinese and the U.S. populations, displaying superior diagnostic relevance compared to TyG.
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