Evidence map›Paper›PMID 39068475›Full record

ArticleBMC research notes2024

Association of rs4588 polymorphism in vitamin D binding protein gene with polycystic ovarian syndrome in Iranian women: a case-control study.

Leila Nazarpoor Akbari, Asma Kheirollahi, Akram Vatannejad, Hediyeh Hamidi

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Article in BMC research notes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leila Nazarpoor AkbariDepartment of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Asma KheirollahiDepartment of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. kheirolahi_asma@ut.ac.ir.
Akram VatannejadDepartment of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Hediyeh HamidiDepartment of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveVitamin D deficiency and variations in the vitamin D binding protein (VDBP) gene may play a role in the development of Polycystic ovary syndrome (PCOS). This study aims to investigate the association of the rs4588 polymorphism with PCOS in Iranian women, as well as its association with infertility and recurrent pregnancy loss (RPL) in these patients.

resultsThe analysis revealed statistically significant differences in the distributions of genotypes and alleles of the rs4588 polymorphism among the three groups (p < 0.0001). The AC genotype and A allele showed an association with an elevated risk of PCOS and infertility. In this study, no association was found between genotypes and alleles of the rs4588 polymorphism and the risk of RPL in women with PCOS. Subjects with the AA or AC genotype exhibited significantly higher levels of LDL compared to those with the CC genotype.

Indexed as

Polycystic Ovary SyndromePolymorphism, Single NucleotideVitamin D-Binding ProteinAbortion, HabitualAdultAllelesCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansInfertility, FemaleIranPregnancyGC protein, humanVitamin D-Binding ProteinInfertilityPolycystic ovary syndromePolymorphismRecurrent pregnancy lossVitamin D binding protein

Identifiers

PMID39068475
PMCPMC11283716

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