Evidence map›Paper›PMID 39068471›Full record

ArticleAlzheimer's research & therapy2024

Sex-specific associations of kynurenic acid with neopterin in Alzheimer's disease.

Anne-Brita Knapskog, Trine Holt Edwin, Per Magne Ueland, Arve Ulvik, Evandro Fei Fang, Rannveig Sakshaug Eldholm, Nathalie Bodd Halaas, Lasse M Giil, Ingvild Saltvedt, Leiv Otto Watne and 1 more

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Article in Alzheimer's research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Anne-Brita KnapskogDepartment of Geriatric Medicine, Oslo University Hospital, 0450, Oslo, Norway.
Trine Holt EdwinDepartment of Geriatric Medicine, Oslo University Hospital, 0450, Oslo, Norway.
Per Magne UelandBevital AS, 5021, Bergen, Norway.
Arve UlvikBevital AS, 5021, Bergen, Norway.
Evandro Fei FangDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway.
Rannveig Sakshaug EldholmDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
Nathalie Bodd HalaasOslo Delirium Research Group, Oslo University Hospital, 0450, Oslo, Norway.
Lasse M GiilNeuro-SysMed, Department of Internal Medicine, Haraldsplass Deaconess Hospital, 5892, Bergen, Norway.
Ingvild SaltvedtDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
Leiv Otto WatneOslo Delirium Research Group, Oslo University Hospital, 0450, Oslo, Norway.
Mari AksnesDepartment of Geriatric Medicine, University of Oslo, 0315, Oslo, Norway. mari.aksnes@medisin.uio.no.

Funding

Akershus Universitetssykehus 269901; 261973; 262960Civitan Norges Forskningsfond for Alzheimers sykdom, Norway 281931Cure Alzheimer's Fund 282952Czech Republic-Norway KAPPA programme, Czech Republic TO01000215Helse Sør-Øst RHF 2017095Helse Sør-Øst RHF 2020001Kreftforeningen 207819Nasjonalforeningen for Folkehelsen,Norway 22679Nasjonalforeningen for Folkehelsen,Norway 25633National Natural Science Foundation of China 81971327NordForsk,Norway 119986Norges Forskningsråd 262175Norges Teknisk-Naturvitenskapelige Universitet 334361VitaDAO, Canada 282942Wellcome Leap 104617
6 · The paper itself

Abstract

backgroundSex differences in neuroinflammation could contribute to women's increased risk of Alzheimer's disease (AD), providing rationale for exploring sex-specific AD biomarkers. In AD, dysregulation of the kynurenine pathway (KP) contributes to neuroinflammation and there is some evidence of sex differences in KP metabolism. However, the sex-specific associations between KP metabolism and biomarkers of AD and neuroinflammation need to be explored further.

methodsHere we investigate sex differences in cerebrospinal fluid concentrations of seven KP metabolites and sex-specific associations with established AD biomarkers and neopterin, an indicator of neuroinflammation. This study included 311 patients with symptomatic AD and 105 age-matched cognitively unimpaired (CU) controls, followed for up to 5 years.

resultsWe found sex differences in KP metabolites in the AD group, with higher levels of most metabolites in men, while there were no sex differences in the CU group. In line with this, more KP metabolites were significantly altered in AD men compared to CU men, and there was a trend in the same direction in AD women. Furthermore, we found sex-specific associations between kynurenic acid and the kynurenic acid/quinolinic acid ratio with neopterin, but no sex differences in the associations between KP metabolites and clinical progression. DISCUSSION: In our cohort, sex differences in KP metabolites were restricted to AD patients. Our results suggest that dysregulation of the KP due to increased inflammation could contribute to higher AD risk in women.

Indexed as

Alzheimer DiseaseBiomarkersKynurenic AcidNeopterinSex CharacteristicsAgedAged, 80 and overFemaleHumansKynurenineMaleMiddle AgedSex FactorsBiomarkersKynurenic AcidKynurenineNeopterinAlzheimer diseaseBiomarkersCerebrospinal fluidKynurenic acidKynurenine pathwayLongitudinal case control studyMitophagyQuinolinic acidSex differencesTryptophan

Identifiers

PMID39068471
PMCPMC11282793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.