ArticleScientific reports2024
Left ventricular dysfunction in pulmonary arterial hypertension is attributed to underfilling rather than intrinsic myocardial disease: a CMR 2D phase contrast study.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Right ventricular longitudinal function is associated with exercise capacity in pre-capillary pulmonary hypertension: a multimodality imaging study.European heart journal. Imaging methods and practice · 2026Article
- Beyond the right ventricle: left heart involvement in pulmonary arterial hypertension.Heart failure reviews · 2026Review
- CMR-derived left ventricular pressure-volume loops enhance individualized assessment of disease severity and prognosis in pulmonary arterial hypertension in adults.Physiological reports · 2026Article
- Cardiac magnetic resonance-derived left heart parameters in pulmonary hypertension: diagnostic and prognostic value-a narrative review.Cardiovascular diagnosis and therapy · 2026Review
- Beyond the right ventricle: assessment of the left ventricular function in pulmonary hypertension.Frontiers in medicine · 2026Review
- Ejection fraction quantification from ungated chest CT by AI.medRxiv : the preprint server for health sciences · 2025Article
- Prognostic Value of Right Ventricular Global Wasted Work in Precapillary Pulmonary Hypertension: A 3D Echocardiographic Study.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Ventricular interdependent phenotype of mixed Cpc-pulmonary hypertension and HFpEF with normal left atrium: Impact on CPET metrics and clinical outcomes.Pulmonary circulation · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The pathophysiology underlying impaired LV function in PAH remains unclear, with some studies implicating intrinsic myocardial dysfunction and others pointing to LV underfilling. Evaluation of pulmonary vein area (PVA) and flow may offer novel, mechanistic insight by distinguishing elevated LV filling pressure common in myocardial dysfunction from LV underfilling. This study aimed to elucidate LV filling physiology in PAH by assessing PVA and flow using cardiac magnetic resonance (CMR) and compare pulmonary vein flow in PAH with HFrEF as a model representing elevated filling pressures, in addition to healthy controls. Patients with PAH or heart failure with reduced ejection fraction (HFrEF) referred for CMR were retrospectively reviewed, and healthy controls were included as reference. Pulmonary vein S, D and A-wave were compared between groups. Associations between pulmonary vein area (PVA) by CMR and echocardiographic indices of LV filling pressure were evaluated. Nineteen patients with PAH, 25 with HFrEF and 24 controls were included. Both PAH and HFrEF had lower ejection fraction and S-wave velocity than controls. PAH displayed smaller LV end-diastolic volumes than controls, while HFrEF demonstrated larger PVA and higher A-wave reversal. PVA was associated with mitral E/e' ratio (r
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Registered trials
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