Evidence map›Paper›PMID 39068280›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2024

Mechanisms of lumbar spine "flattening" in adult spinal deformity: defining changes in shape that occur relative to a normative population.

Renaud Lafage, Frank Mota, Marc Khalifé, Themistocles Protopsaltis, Peter G Passias, Han-Jo Kim, Breton Line, Jonathan Elysée, Gregory Mundis, Christopher I Shaffrey and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Renaud LafageDepartment of Orthopedic Surgery, Northwell Health, Lenox Hill Hospital, New York, NY, USA.
Frank MotaDepartment of Orthopedic Surgery, Northwell Health, Lenox Hill Hospital, New York, NY, USA.
Marc KhaliféDepartment of Orthopedic Surgery, Northwell Health, Lenox Hill Hospital, New York, NY, USA. marc.khalife@aphp.fr.ORCID http://orcid.org/0000-0001-9022-3336
Themistocles ProtopsaltisDepartment of Orthopedics, Division of Spine, NYU Langone Health, New York, NY, USA.
Peter G PassiasDepartment of Orthopedics, Division of Spine, NYU Langone Health, New York, NY, USA.
Han-Jo KimDepartment of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.
Breton LineDepartment of Spine Surgery, Denver International Spine Clinic, Presbyterian St. Luke's/Rocky Mountain Hospital for Children, Denver, CO, USA.
Jonathan ElyséeDepartment of Orthopedic Surgery, Northwell Health, Lenox Hill Hospital, New York, NY, USA.
Gregory MundisDivision of Orthopedic Surgery, Scripps Clinic, La Jolla, San Diego, CA, USA.
Christopher I ShaffreyDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Christopher P AmesDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Eric O KlinebergDepartment of Orthopedic Surgery, University of California Davis, Sacramento, CA, USA.
Munish C GuptaDepartment of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Douglas C BurtonDepartment of Orthopedic Surgery, Medical Center, University of Kansas, Kansas City, KS, USA.
Lawrence G LenkeDepartment of Orthopedic Surgery, The Och Spine Hospital, Columbia University Irving Medical Center, New York, NY, USA.
Shay BessDepartment of Spine Surgery, Denver International Spine Clinic, Presbyterian St. Luke's/Rocky Mountain Hospital for Children, Denver, CO, USA.
Justin S SmithDepartment of Neurosurgery, University of Virginia, Charlottesville, VA, USA.
Frank J SchwabDepartment of Orthopedic Surgery, Northwell Health, Lenox Hill Hospital, New York, NY, USA.
Virginie LafageDepartment of Orthopedic Surgery, Northwell Health, Lenox Hill Hospital, New York, NY, USA.
ISSG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious work comparing ASD to a normative population demonstrated that a large proportion of lumbar lordosis is lost proximally (L1-L4). The current study expands on these findings by collectively investigating regional angles and spinal contours.

methods119 asymptomatic volunteers with full-body free-standing radiographs were used to identify age-and-PI models of each Vertebra Pelvic Angle (VPA) from L5 to T10. These formulas were then applied to a cohort of primary surgical ASD patients without coronal malalignment. Loss of lumbar lordosis (LL) was defined as the offset between age-and-PI normative value and pre-operative alignment. Spine shapes defined by VPAs were compared and analyzed using paired t-tests.

results362 ASD patients were identified (age = 64.4 ± 13, 57.1% females). Compared to their age-and-PI normative values, patients demonstrated a significant loss in LL of 17 ± 19° in the following distribution: 14.1% had "No loss" (mean = 0.1 ± 2.3), 22.9% with 10°-loss (mean = 9.9 ± 2.9), 22.1% with 20°-loss (mean = 20.0 ± 2.8), and 29.3% with 30°-loss (mean = 33.8 ± 6.0). "No loss" patients' spine was slightly posterior to the normative shape from L4 to T10 (VPA difference of 2°), while superimposed on the normative one from S1 to L2 and became anterior at L1 in the "10°-loss" group. As LL loss increased, ASD and normative shapes offset extended caudally to L3 for the "20°-loss" group and L4 for the "30°-loss" group.

conclusionAs LL loss increases, the difference between ASD and normative shapes first occurs proximally and then progresses incrementally caudally. Understanding spinal contour and LL loss location may be key to achieving sustainable correction by identifying optimal and personalized postoperative shapes.

Indexed as

LordosisLumbar VertebraeAdultAgedFemaleHumansMaleMiddle AgedRadiographyAdult spinal deformityFlat backLumbar lordosisSpinal shapeVertebral pelvic angle

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.