Evidence map›Paper›PMID 39068003›Full record

ReviewGastroenterology clinics of North America2024

Chimerism-Mediated Tolerance in Intestinal Transplantation.

Kevin Crosby, Katherine D Long, Jianing Fu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastroenterology clinics of North America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kevin CrosbyColumbia University Medical Center, New York, NY 10032, USA.
Katherine D LongWashington University School of Medicine in St. Louis, St Louis, MO 63110, USA.
Jianing FuDepartment of Medicine, Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: jf2977@cumc.columbia.edu.

Funding

Transcriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3M
Training Medical Students in NIDDK ResearchT35DK093430 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QAIS AL-AWQATI, Utpal Pajvani · 2012 to 2026
$1.3M
Immune profiling of γδ T cells after human intestinal transplantationR21AI166069 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FU, JIANING · 2021 to 2022
$446k
NIAID NIH HHS P01 AI106697NIAID NIH HHS R21 AI166069NIDDK NIH HHS T35 DK093430
6 · The paper itself

Abstract

In this review, the authors outlined concepts and strategies to achieve immune tolerance through inducing hematopoietic chimerism after solid organ transplantation and introduced challenges and opportunities in harnessing two-way alloresponses to improve outcomes after intestinal transplantation (ITx). Next, the authors discussed the dynamics and phenotypes of peripheral blood and intestinal graft T-cell subset chimerism and their association with outcomes. The authors also summarized studies on other types of immune cells after ITx and their potential participation in chimerism-mediated tolerance. The authors further discussed strategies and future directions to promote chimerism-associated tolerance after ITx to overcome rejection and minimize immunosuppression.

Indexed as

IntestinesTransplantation ChimeraChimerismGraft RejectionHumansImmune ToleranceOrgan TransplantationTransplantation ToleranceBidirectional alloresponsesChimerismIntestinal transplantationLGVHRTolerance

Identifiers

PMID39068003
PMCPMC11284277

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.