ArticleAnnals of vascular surgery2025
Contemporary National Incidence and Outcomes of Acute Limb Ischemia.
Article in Annals of vascular surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Optimizing identification of major adverse limb and cardiovascular events among adults with peripheral artery disease in administrative data.Journal of vascular surgery · 2026Article
- Female patients with vascular disease receive less medical optimization despite more health care utilization.Journal of vascular surgery · 2026Article
- Endovascular dual internal-external iliac balloon occlusion creates a reproducible porcine survival model of unilateral acute hindlimb ischemia.JVS-vascular science · 2026Article
- Female patients at increased risk for adverse outcomes after acute limb ischemia.Journal of vascular surgery · 2026Article
- Acute limb ischemia secondary to left brachial artery occlusion in a 45-year-old woman: A case report.Medicine · 2025Article
- Predictors of Post-Amputation Complications in Major Lower Limb Amputations: The Role of WIfI Scoring and Pre-Amputation Transcutaneous Oximetry (TcPO2).International wound journal · 2025Article
- POCUS-Guided Forearm Nerve Blocks for Analgesia of Acute Hand Ischemia in the Emergency Department.POCUS journal · 2025Article
- Peripheral artery disease.Nature reviews. Disease primers · 2025Review
- Comparison of open and endovascular therapy for infrainguinal acute limb ischemia in the era of percutaneous thrombectomy.Journal of vascular surgery · 2025Article
- Clinical Features of Acute on Chronic Lower Limb Ischemia and the Importance of Underlying Arterial Disease for Revascularization.Circulation reports · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundAcute limb ischemia (ALI) is a morbid and deadly diagnosis. However, existing epidemiologic studies describing ALI predate the introduction of the Affordable Care Act in 2010 and direct oral anticoagulants in 2011. Thus, we synergized the National Inpatient Sample (NIS) and United States Census to define contemporary trends in the incidence, treatment, and outcomes of ALI in the US.
methodsWe included emergent admissions of adults with primary diagnosis of lower extremity ALI in survey-weighted NIS data (2005-2020). Mann-Kendal trend test evaluated ALI incidence (primary outcome), anticoagulation usage, insurance coverage, revascularization type, and in-hospital amputation/death. Multivariable logistic regression quantified covariate associations with in-hospital amputation/death.
resultsOf the 582,322,862 estimated hospitalizations in the NIS, 227,440 met the inclusion criteria (mean age 68.80 years, 49.94% women, 76.66% White). ALI incidence peaked in 2006 (7.16/100,000 person-years) but has declined since 2015 to 4.16/100,000 person-years in 2020 (p
conclusionsOur US population based epidemiological study demonstrates that ALI incidence and in-hospital amputation rates are decreasing, while mortality remains unchanged. We further highlight the ongoing need for ALI investigation specifically as it relates to access to care, antithrombotic therapy use, treatment strategy, and strategies to combat gender and racial disparities.
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