Evidence map›Paper›PMID 39067415›Full record

ArticleHearing research2024

A new mutation of Sgms1 causes gradual hearing loss associated with a reduced endocochlear potential.

Jing Chen, Morag A Lewis, Alisa Wai, Lucia Yin, Sally J Dawson, Neil J Ingham, Karen P Steel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. A Systematic Review of Genes Affecting Endocochlear Potential.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Pooled it
  2. A Systematic Review on the Role of the Stria Vascularis in Menière's Disease Pathogenesis.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Investigating the effects of a cryptic splice site in the En2 splice acceptor sequence used in the IKMC knockout-first alleles.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing ChenWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, United Kingdom.
Morag A LewisWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, United Kingdom.
Alisa WaiWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, United Kingdom.
Lucia YinWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, United Kingdom.
Sally J DawsonUCL Ear Institute, University College London, London WC1X 8EE, United Kingdom.
Neil J InghamWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, United Kingdom.
Karen P SteelWolfson Sensory, Pain and Regeneration Centre, King's College London, London SE1 1UL, United Kingdom. Electronic address: karen.steel@kcl.ac.uk.

Funding

Medical Research Council G0300212Medical Research Council MR/N012119/1Wellcome Trust 221769/Z/20/ZWellcome Trust WT089622MAWellcome Trust WT098051Wellcome Trust WT100699MA
6 · The paper itself

Abstract

Sgms1 encodes sphingomyelin synthase 1, an enzyme in the sphingosine-1-phosphate signalling pathway, and was previously reported to underlie hearing impairment in the mouse. A new mouse allele, Sgms1

Indexed as

Evoked Potentials, Auditory, Brain StemHearing LossStria VascularisTransferases (Other Substituted Phosphate Groups)AnimalsAuditory ThresholdCochleaDisease Models, AnimalFemaleGenetic Predisposition to DiseaseHearingHomozygoteMaleMiceMice, Inbred C57BLMice, KnockoutSgms1 protein, mouseTransferases (Other Substituted Phosphate Groups)Endocochlear potentialProgressive hearing lossSgms1Sphingosine-1-phosphate signallingStria vascularis

Identifiers

PMID39067415
PMCPMC7619117

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.