Evidence map›Paper›PMID 39066908›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2024

Repetitive Administration of Low-Dose Lipopolysaccharide Improves Repeated Social Defeat Stress-Induced Behavioral Abnormalities and Aberrant Immune Response.

Vichuda Charoensaensuk, Wei-Lan Yeh, Bor-Ren Huang, Tsung-Che Hsu, Sheng-Yun Xie, Chao-Wei Chen, Yu-Wen Wang, Liang-Yo Yang, Cheng-Fang Tsai, Dah-Yuu Lu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Immune system evaluation of Echinacea Purpurea root extract in female Harlan Sprague Dawley (Hsd:Sprague Dawley SD) rats.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vichuda Charoensaensuk *Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan.
Wei-Lan Yeh *Department of Biochemistry, School of Medicine, China Medical University, Taichung, 40402, Taiwan.
Bor-Ren HuangDepartment of Neurosurgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan.
Tsung-Che HsuSchool of Medicine, China Medical University, Taichung, 40402, Taiwan.
Sheng-Yun XieDepartment of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan.
Chao-Wei ChenInstitute of New Drug Development, China Medical University, Taichung, Taiwan.
Yu-Wen WangDepartment of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu, Taiwan.
Liang-Yo YangDepartment of Physiology, School of Medicine, China Medical University, Taichung, 404328, Taiwan.
Cheng-Fang TsaiDepartment of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan.
Dah-Yuu LuDepartment of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan. dahyuu@mail.cmu.edu.tw.

Funding

National Science and Technology Council 112-2811-B-039 -002 - and 110-2320-B-039 -028 -MY3
6 · The paper itself

Abstract

Repetitive exposure of innate immune cells to a subthreshold dosage of endotoxin components may modulate inflammatory responses. However, the regulatory mechanisms in the interactions between the central nervous system (CNS) and the immune system remain unclear. This study aimed to investigate the effects of lipopolysaccharide (LPS) preconditioning in repeated social defeat stress (RSDS)-induced abnormal immune responses and behavioral impairments. This study aimed to elucidate the mechanisms that underlie the protective effects of repeated administration of a subthreshold dose LPS on behavioral impairments using the RSDS paradigm. LPS preconditioning improved abnormal behaviors in RSDS-defeated mice, accompanied by decreased monoamine oxidases and increased glucocorticoid receptor expression in the hippocampus. In addition, pre-treated with LPS significantly decreased the recruited peripheral myeloid cells (CD11b

Indexed as

LipopolysaccharidesMice, Inbred C57BLSocial DefeatStress, PsychologicalAnimalsBehavior, AnimalHippocampusLipocalin-2MaleMiceMicrogliaLipocalin-2LipopolysaccharidesChemokineLipocalin-2LPS toleranceMicrogliaRSDS

Identifiers

PMID39066908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.