Evidence map›Paper›PMID 39066903›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2024

Impact of a short-term Mediterranean diet intervention on plasma metabolites: a pilot study.

E Smith, F Ottosson, U Ericson, S Hellstrand, M Rizzo, K Sukruang, V Pizza, M Orho-Melander, P M Nilsson, C Kennbäck and 4 more

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Article in Metabolomics : Official journal of the Metabolomic Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

E SmithDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden. Einar.smith@med.lu.se.
F OttossonDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
U EricsonDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
S HellstrandDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
M RizzoGREAT Health Sciences, Rome, Italy.
K SukruangFaculty of Medicine Ramathibodi Hospital, Chakri Naruebodindra Medical Institute, Mahidol University, Samut Prakan, Thailand.
V PizzaDepartment of Emergency and Time Dependent Networks, Neurology Unit, S.Luca Hospital, Vallo Della Lucania, Italy.
M Orho-MelanderDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
P M NilssonDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
C KennbäckDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
C FernandezDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
P AntoniniGREAT Health Sciences, Rome, Italy.
S Di SommaGREAT Health Sciences, Rome, Italy.
O MelanderDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.

Funding

European Research Council AdG 2019-885003Hjärt-Lungfonden Dnr 20180278Lunds Universitet Artificially Intelligent use of Registers at Lund UniversityNovo Nordisk Fonden NNF200C0063465Stiftelsen för Strategisk Forskning IRC LUDCVetenskapsrådet SFO-EXODIAB
6 · The paper itself

Abstract

backgroundDietary habits significantly influence the risks of type 2 diabetes and cardiovascular disease. Through metabolomics, we've previously measured plasma metabolites to gauge dietary quality, introducing a healthy dietary metabolic signature (HDMS) linked to a decreased risk of future type 2 diabetes and coronary artery disease.

objectivesTo assess the impact of a 6-day dietary intervention on plasma metabolites and the HDMS.

methodsFifty-nine Swedish participants (71% women, mean age 69 years) underwent a 6-day Mediterranean diet (MD) intervention in Italy's Cilento region. All meals, crafted from local recipes and ingredients, were provided. Metabolite profiling pre- and post-intervention was conducted with a UHPLC-QTOF. Alterations in metabolite levels and the HDMS were examined using paired T-test.

resultsThe MD intervention notably enhanced the HDMS across participants (mean increase: 1.3 standard deviations (SD), 95% CI 1.1-1.4, p = 6E-25). Out of 109 metabolites, 66 exhibited significant alterations (fdr adjusted p < 0.05). Among the 10 most significant changes, increases were observed in several diet related metabolites such as pipecolate, hippurate, caffeine, homostachydrine, acylcarnitine C11:0, acetylornithine, beta-carotene and 7-methylguanine. The most significant decreases manifested in piperine and 3-methylhistidine.

conclusionsThe HDMS, which is linked to a healthy diet and inversely associated with cardiometabolic disease, was significantly improved by the 6-day Mediterranean diet intervention. Notably, metabolite markers previously shown to be indicative of the intake of vegetables, fruits, grains, and legumes increased, while markers previously associated with red meat consumption decreased. These findings highlight the potential of short-term dietary interventions to induce significant changes in plasma metabolite profiles.

Indexed as

Diet, MediterraneanAgedDiabetes Mellitus, Type 2FemaleHumansMaleMetabolomeMetabolomicsMiddle AgedPilot ProjectsSwedenCardiovascular diseaseMediterranean dietNutritionNutritional metabolomicsType 2 diabetes

Identifiers

PMID39066903
PMCPMC11283393

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.