Evidence map›Paper›PMID 39066891›Full record

ArticleCellular and molecular life sciences : CMLS2024

ZMYND12 serves as an IDAd subunit that is essential for sperm motility in mice.

Chang Wang, Qingsong Xie, Xun Xia, Chuanying Zhang, Shan Jiang, Sihan Wang, Xi Zhang, Rong Hua, Jiangyang Xue, Haoyu Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chang Wang *College of Nursing, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.
Qingsong Xie *Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China.
Xun Xia *Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China.
Chuanying ZhangCollege of Nursing, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.
Shan JiangCollege of Nursing, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.
Sihan WangCollege of Nursing, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.
Xi ZhangDepartment of Reproductive Health and Infertility Clinic, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, China.
Rong HuaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China. ahmuhuarong@126.com.ORCID http://orcid.org/0000-0001-9607-6605
Jiangyang XueThe Central Laboratory of Birth Defects Prevention and Control, Ningbo Key Laboratory for the Prevention and Treatment of Embryogenic Diseases, Women and Children's Hospital of Ningbo University, Ningbo, Zhejiang, 315000, China. jiangyxvet@sina.com.
Haoyu ZhengDepartment of Gynaecology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, China. zhenghaoyu89@126.com.

Funding

Anhui Provincial Department of Science and Technology 2208085Y31Huai'an Municipal Science and Technology Bureau HAB202305National Natural Science Foundation of China 32000584National Natural Science Foundation of China 82371622Natural Science Foundation of Ningbo Municipality 2023Z178the exceptional support plan of talent introduction of Anhui University of Chinese Medicine 2023rcyb022the Key Project of Natural Science Foundation for Universities of Anhui Province Education Department 2023AH050843the Science and Technology development Fundation of Nanjing Medical Univertisy NMUB20220214
6 · The paper itself

Abstract

Inner dynein arms (IDAs) are formed from a protein complex that is essential for appropriate flagellar bending and beating. IDA defects have previously been linked to the incidence of asthenozoospermia (AZS) and male infertility. The testes-enriched ZMYND12 protein is homologous with an IDA component identified in Chlamydomonas. ZMYND12 deficiency has previously been tied to infertility in males, yet the underlying mechanism remains uncertain. Here, a CRISPR/Cas9 approach was employed to generate Zmynd12 knockout (Zmynd12

Indexed as

Infertility, MaleMice, KnockoutSperm MotilityAnimalsAsthenozoospermiaContactin 2CRISPR-Cas SystemsDyneinsHumansMaleMiceMice, Inbred C57BLSpermatozoaSperm CapacitationContactin 2DyneinsIDAKnockout miceMale fertilityPRKACASpermatogenesis

Identifiers

PMID39066891
PMCPMC11335240

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.