Evidence map›Paper›PMID 39066871›Full record

ArticleJournal of clinical monitoring and computing2024

Prone-position decreases airway closure in a patient with ARDS undergoing venovenous extracorporeal membrane oxygenation.

Marco Giani, Andrea Restivo, Davide Raimondi Cominesi, Rosa Fracchia, Matteo Pozzi, Lorenzo Del Sorbo, Giuseppe Foti, Laurent Brochard, Emanuele Rezoagli

Registry-linked trialAbstract readLetter
PubMed Publisher
In one paragraph

Article in Journal of clinical monitoring and computing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07019831 (Imaging the Respiratory Effects of Truncal Adiposity in Healthy Subjects), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07019831 nanot yet recruitingnot on this mapstarted 2028, after this paper: background citation

Imaging the Respiratory Effects of Truncal Adiposity in Healthy Subjects

TypeinterventionalSponsorMaurizio F. Cereda, MDRan2028 to 2030Enrolled20ConditionsHealthy Volunteers OnlyArmsBody positioning
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marco GianiSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0001-8048-2721
Andrea RestivoSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0009-0005-9489-1952
Davide Raimondi CominesiSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0009-0009-2305-4531
Rosa FracchiaSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Matteo PozziSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0001-8235-9313
Lorenzo Del SorboInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Giuseppe FotiSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-8698-2046
Laurent BrochardInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Emanuele RezoagliSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. emanuele.rezoagli@unimib.it.ORCID 0000-0002-4506-7212

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAirway closure is a interruption of communication between larger and smaller airways. The presence of airway closure during mechanical ventilation may lead to the overestimation of driving pressure (DP), introducing errors in the assessment of respiratory mechanics and in positive end-expiratory pressure (PEEP) setting on the ventilator. Patients with severe acute respiratory distress syndrome (ARDS) may exhibit the airway closure phenomenon, which can be easily diagnosed with a low-flow inflation. Prone positioning is a therapeutic manoeuver proven to reduce mortality in ARDS patients, and has been widely implemented also in patients requiring veno-venous extracorporeal membrane oxygenation (V-V ECMO). To date, the impact of prone positioning on changes in airway closure has not been described.

methodsWe present an image analysis of the pressure waveform during volume-controlled ventilation and low-flow inflations before and after prone positioning in an ARDS patient on VV ECMO.

resultsA high airway opening pressure level (23 cmH

conclusionProne positioning reduced airway closure in an ARDS patient on VV ECMO support.

Indexed as

Extracorporeal Membrane OxygenationPositive-Pressure RespirationRespiration, ArtificialRespiratory Distress SyndromeAdultHumansMaleMiddle AgedPatient PositioningPressureProne PositionRespiratory MechanicsTidal VolumeAcute respiratory distress syndromeAirway closureDriving pressureProne positionRespiratory mechanicsVeno-venous extracorporeal membrane oxygenation

Identifiers

PMID39066871

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.