Evidence map›Paper›PMID 39066842›Full record

ArticlePituitary2024

The diverging role of O-GlcNAc transferase in corticotroph and somatotroph adenomas.

Roel Gonzalez, Logan Massman, Sophia Ho, Sarai Luna, Stephanie Cheok, Brandon Liang, Kelly Mrachek, Dylan Coss, Adriana G Ioachimescu, Nathan Zwagerman and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pituitary, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Roel Gonzalez *Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA.
Logan Massman *Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA.
Sophia HoDepartment of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA.
Sarai LunaDepartment of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA.
Stephanie CheokDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Brandon LiangDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Kelly MrachekDepartment of Pathology & Laboratory Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Dylan CossDepartment of Pathology & Laboratory Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Adriana G IoachimescuDepartment of Endocrinology and Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Nathan ZwagermanDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Stephanie Olivier-Van StichelenDepartment of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA. solivier@mcw.edu.

Funding

Placental Hormones and O-GlcNAcylation in Gestational DiabetesR01HD104808 · NICHD · MEDICAL COLLEGE OF WISCONSIN · PI Stephanie Olivier-Van Stichelen · 2022 to 2026
$1.8M
Nutrient sensing O-GlcNAcylation in pituitary developmentR00HD087430 · NICHD · MEDICAL COLLEGE OF WISCONSIN · PI OLIVIER-VAN STICHELEN, STEPHANIE · 2019 to 2021
$737k
NICHD NIH HHS R00 HD087430NICHD NIH HHS R01 HD104808
6 · The paper itself

Abstract

purposeMolecular mechanisms involved in the pathogenesis and tumor progression of pituitary adenomas (PA) remain incompletely understood. Corticotroph and somatotroph PA are associated with a high clinical burden, and despite improved surgical outcomes and medical treatment options, they sometimes require multiple surgeries and radiation. Preliminary data suggested a role for O-GlcNAc Transferase (OGT), the enzyme responsible for the O-GlcNAcylation of proteins. O-GlcNAcylation and OGT have been found elevated in other types of tumors.

methodsWe evaluated 60 functioning and nonfunctioning PA (NFPA) from operated patients and postmortem normal and tumoral pituitary tissue by immunohistochemistry. We performed transcriptomic analyses to explore the relevance of the O-GlcNAc Transferase (OGT) in PAs. We detected OGT in immunobiological analysis and define its level in PA tissue in patients.

resultsOGT was strongly associated with PA hormone secretory capacity in functioning PA and with tumor growth in NFPAs. In NFPAs, OGT was positively associated with tumor size but not with cavernous sinus invasion (Knosp grading). In GH-secreting PA, OGT expression was negatively correlated with circulating Insulin-like Growth Factor 1 level. In adrenocorticotropic hormone (ACTH)-secreting PA, OGT expression was positively associated with circulating ACTH levels. OGT did not correlate with tumor size in secreting PAs. OGT levels were higher in gonadotroph PA compared to normal glands.

conclusionO-GlcNAcylation can be downregulated in non-cancerous tumors such as GH-secreting adenomas. Future studies are warranted to elucidate the role of OGT in the pathogenesis of PAs.

Indexed as

N-AcetylglucosaminyltransferasesPituitary NeoplasmsACTH-Secreting Pituitary AdenomaAdenomaAdultAgedCorticotrophsFemaleGrowth Hormone-Secreting Pituitary AdenomaHumansMaleMiddle AgedN-AcetylglucosaminyltransferasesO-GlcNAc transferaseCorticotroph adenomaO-GlcNAc transferaseO-GlcNAcylationPituitary adenomasSomatotroph adenoma

Identifiers

PMID39066842
PMCPMC12147819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.