Evidence map›Paper›PMID 39066830›Full record

ArticlePurinergic signalling2025

Assessment of ATP metabolism to adenosine by ecto-nucleotidases carried by tumor-derived small extracellular vesicles.

Chang-Sook Hong, Elizabeth V Menshikova, Theresa L Whiteside, Edwin K Jackson

Abstract read
In one paragraph

Article in Purinergic signalling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Chang-Sook HongDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Elizabeth V MenshikovaDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Theresa L WhitesideDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. whitesidetl@upmc.edu.ORCID 0000-0001-7316-6181
Edwin K JacksonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

Depleting exosomes to improve responses to immune therapy in HNSCCU01DE029759 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITESIDE, THERESA L. · 2020 to 2024
$3.5M
Small extracellular vesicles as biomarkers of prognosis and response to therapy in head and neck cancerR01DE031299 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Brenda B. Diergaarde, Theresa L. Whiteside · 2023 to 2026
$2.9M
The Adenosinergic Pathway in Tumor-derived ExosomesR01CA256068 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY, WHITESIDE, THERESA L. · 2021 to 2025
$2.5M
NCI NIH HHS R01 CA256068NIDCR NIH HHS R01 DE031299NIDCR NIH HHS U01 DE029759NIH HHS R01-CA 256068NIH HHS UO1-DE029759
6 · The paper itself

Abstract

Immunosuppression is a hallmark of cancer progression. Tumor-derived small extracellular vesicles (sEV), also known as TEX, produce adenosine (ADO) and can mediate tumor-induced immunosuppression.Here, the ATP pathway of ADO production (ATP

Indexed as

AdenosineAdenosine TriphosphatasesAdenosine TriphosphateExtracellular VesiclesMelanomaCell Line, TumorHumansAdenosineAdenosine TriphosphatasesAdenosine TriphosphateDerivedHigh pressure liquid chromatographyN6-etheno-adenosineN6-etheno-ADPN6-etheno-AMPN6-etheno-ATPSmall extracellularTumorVesicles

Identifiers

PMID39066830
PMCPMC12061804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.