ArticleMetabolomics : Official journal of the Metabolomic Society2024
Acylcarnitines are associated with lower depressive symptomatology in a mainland puerto rican cohort.
Article in Metabolomics : Official journal of the Metabolomic Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Serum metabolites associated with depression and anxiety in the Hispanic Community Health Study/Study of Latinos.Translational psychiatry · 2026Observational
- Serum Metabolites Associated with Depression and Anxiety in the Hispanic Community Health Study/Study of Latinos.medRxiv : the preprint server for health sciences · 2025Article
- Acylcarnitines metabolism in depression: association with diagnostic status, depression severity and symptom profile in the NESDA cohort.Translational psychiatry · 2025Article
- A network-based approach to discover diagnostic metabolite markers associated with depressive features for major depressive disorder.Frontiers in psychiatry · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
introductionRecent studies have implicated acetyl-L-carnitine as well as other acylcarnitines in depression. To our knowledge, no untargeted metabolomics studies have been conducted among US mainland Puerto Ricans.
objectivesWe conducted untargeted metabolomic profiling on plasma from 736 participants of the Boston Puerto Rican Health Study.
methodsUsing Weighted Gene Co-expression Network Analysis, we identified metabolite modules associated with depressive symptomatology, assessed via the Center for Epidemiologic Studies Depression scale. We identified metabolites contributing to these modules and assessed the relationship between these metabolites and depressive symptomatology.
results621 annotated metabolites clustered into eight metabolite modules, of which one, the acylcarnitine module, was significantly inversely associated with depressive symptomatology (β = - 27.7 (95% CI (- 54.5-0.8); p = 0.043). Several metabolite hub features in the acylcarnitine module were significantly associated with depressive symptomatology, after correction for multiple comparisons.
conclusionsIn this untargeted plasma metabolomics study among mainland Puerto Rican older adults, acylcarnitines, as a metabolite module were inversely associated with depressive symptomatology.
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