Evidence map›Paper›PMID 39066817›Full record

ArticleMolecular biology reports2024

Prevalence and characterization of quinolone resistance and integrons in clinical Gram-negative isolates from Gaza strip, Palestine.

Ghassan Tayh, Imene Fhoula, Mourad Ben Said, Abdellatif Boudabous, Karim Ben Slama

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ghassan TayhLaboratory of Microorganisms and Active Biomolecules, Faculty of Sciences of Tunis, University of Tunis El Manar, LR03ES03, Tunis, Tunis 2092, Tunisia. ghassan.tayh@gmail.com.ORCID http://orcid.org/0000-0002-7180-6787
Imene FhoulaLaboratory of Microbiology-Biochemistry, Aziza Othmana Hospital, University of Tunis, Tunis, 1008, Tunisia.
Mourad Ben SaidDepartment of Microbiology and Immunology, National School of Veterinary Medicine, University of Manouba, LR16AGR01, Sidi Thabet 2020, Ariana, Tunisia.
Abdellatif BoudabousLaboratory of Microorganisms and Active Biomolecules, Faculty of Sciences of Tunis, University of Tunis El Manar, LR03ES03, Tunis, Tunis 2092, Tunisia.
Karim Ben SlamaLaboratory of Microorganisms and Active Biomolecules, Faculty of Sciences of Tunis, University of Tunis El Manar, LR03ES03, Tunis, Tunis 2092, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGram-negative bacteria with quinolone resistance and extended-spectrum beta-lactamases (ESBLs) present significant treatment challenges. This study evaluated the prevalence and characteristics of quinolone resistance in Gram-negative strains, investigating the relationship between plasmid-mediated quinolone resistance (PMQR), ESBLs, and integrons. METHODS AND

resultsWe collected 146 Gram-negative isolates from patients in three Palestinian hospitals. For quinolone resistance isolates, the presence and characterization of PMQR, β-lactamase genes and integrons were studied by PCR and sequencing. Out of 146 clinical isolates, 64 (43.8%) were resistant to quinolones, with 62 (97%) being multidrug-resistant (MDR) and 33 (51.5%) ESBL-producers. PMQR-encoding genes were present in 45 (70.3%) isolates, including aac(6')-Ib-cr (26.6%), qnrA (18.8%), qnrS1 (20.8%), and qnrB (6.4%). Bla

conclusionsThis study found a high rate of quinolone resistance, ESBL and integrons in clinical Gram-negative isolates from our hospitals. Urgent measures are crucial, including implementing an antimicrobial resistance surveillance system, to control and continuously monitor the development of antimicrobial resistance.

Indexed as

Anti-Bacterial AgentsGram-Negative BacteriaIntegronsMicrobial Sensitivity TestsQuinolonesbeta-LactamasesDrug Resistance, BacterialDrug Resistance, Multiple, BacterialGram-Negative Bacterial InfectionsHumansMiddle EastPlasmidsPrevalenceAnti-Bacterial Agentsbeta-LactamasesQuinolonesExtended-spectrum-beta-lactamase (ESBL)Gram negative bacteriaIntegronsMulti-drug resistant (MDR)Qnr genesQuinolone resistance genes

Identifiers

PMID39066817

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