Evidence map›Paper›PMID 39066796›Full record

ArticleMikrochimica acta2024

Laminarin-modulated osmium nanozymes with high substrate-affinity and selective peroxidase-like behavior engineered colorimetric assay for hydroxyl radical scavenging capacity estimation.

Feng-Lin Lin, Xiao-Yun Guo, Huan-Ran Shen, Xiu-Mei Guo, Yun Dai, Qiong-Hua Zheng, Jin-Cheng Chen, Qiu-Xia Xu, Yin Zhang, Shao-Bin He and 1 more

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Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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11 authors.

Feng-Lin Lin *Department of Pharmacy, Quanzhou Women's and Children's Hospital, Quanzhou, 362000, China.
Xiao-Yun Guo *Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou, 350004, China.
Huan-Ran ShenHigher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou, 350004, China.
Xiu-Mei GuoLaboratory of Clinical Pharmacy, Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China.
Yun DaiDepartment of Pharmacy, Quanzhou Women's and Children's Hospital, Quanzhou, 362000, China.
Qiong-Hua ZhengHigher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou, 350004, China.
Jin-Cheng ChenLaboratory of Clinical Pharmacy, Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China.
Qiu-Xia XuLaboratory of Clinical Pharmacy, Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China.
Yin ZhangLaboratory of Clinical Pharmacy, Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China. zyin1973@163.com.
Shao-Bin HeHigher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou, 350004, China. hesb@fjmu.edu.cn.ORCID http://orcid.org/0000-0003-0888-9118
Wei ChenHigher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou, 350004, China. chenandhu@163.com.ORCID http://orcid.org/0000-0003-3233-8877

Funding

Introduced High-Level Talent Team Project of Quanzhou City 2023CT008Joint Funds for the Innovation of Science and Technology, Fujian Province 2023Y9226Natural Science Foundation of Fujian Province 2022J01271Science and Technology Program of Quanzhou 2024NY069
6 · The paper itself

Abstract

Hydroxyl radical (·OH) scavenging capacity (HOSC) estimation is essential for evaluating antioxidants, natural extracts, or drugs against clinical diseases. While nanozymes offer advantages in related applications, they still face limitations in activity and selectivity. In response, this work showcases the fabrication of laminarin-modulated osmium (laminarin-Os) nanoclusters (1.45 ± 0.05 nm), functioning as peroxidase-like nanozymes within a colorimetric assay tailored for rational HOSC estimation. This study validates both the characterization and remarkable stability of laminarin-Os. By leveraging the abundant surface negative charges of laminarin-Os and the surface hydroxyls of laminarin, oxidation reactions are facilitated, augmenting laminarin-Os's affinity for 3,3',5,5'-tetramethylbenzidine (TMB) (K

Indexed as

BenzidinesFree Radical ScavengersGlucansHydroxyl RadicalOsmiumColorimetryOxidation-ReductionPeroxidase3,3',5,5'-tetramethylbenzidineBenzidinesFree Radical ScavengersGlucansHydroxyl RadicallaminaranOsmiumPeroxidaseColorimetric assayHydroxyl radical scavenging capacityLaminarinNanozymeOsmium nanoclustersPeroxidase-like

Identifiers

PMID39066796

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