ArticleEnvironmental science & technology2024
Assessing Per- and Polyfluoroalkyl Substances in Fish Fillet Using Non-Targeted Analyses.
Article in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Integrating Computational Chemistry and Ion Mobility Spectrometry into Non-Targeted Analysis Workflows for the Structural Elucidation of Emerging PFAS.Journal of the American Society for Mass Spectrometry · 2026Article
- Uncovering PFAS and halogenated chemicals using nontargeted analysis and the PFAS IMplementer for mass spectrometry (PIMMS).Science advances · 2026Article
- Mood Altering Waters: Multidimensional Profiling and Chiral Characterization of Antidepressants in Effluent-Impacted Waterways.Environmental science & technology · 2026Article
- Maternal PFAS transfer through lactation: dolphin milk reveals routes of early-life exposure.Analytical and bioanalytical chemistry · 2026Article
- Review
- Increasing PFAS concentrations in human serum correlate with elevated blood lipid levels.Environmental science. Advances · 2026Article
- Evaluating Legacy and Emerging PFAS in Human Blood Collected from 2003 to 2021.Environmental science & technology · 2026Article
- Selecting the Correct Autosampler Vial and Insert to Improve Reproducibility and Accuracy in Mass Spectrometry Analyses.International journal of mass spectrometry · 2025Article
- Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry.Environmental science & technology · 2025Article
- Global Access to Uncontaminated Omega-3 Polyunsaturated Fatty Acids Requires Attention.AJPM focus · 2025Article
- Novel PFAS in alligator blood discovered with non-targeted ion mobility spectrometry-mass spectrometry.The Science of the total environment · 2025Article
- Evaluating Ion Mobility Data Acquisition, Calibration, and Processing for Small Molecules: A Cross-Platform Assessment of Drift Tube and Traveling Wave Methodologies.Journal of the American Society for Mass Spectrometry · 2025Article
- Spatial Trends and Health Risks of Per- and Polyfluoroalkyl Substances in San Francisco Bay Fish from 2009 to 2019.ACS ES&T water · 2025Article
- Novel PFAS in Alligator Blood Discovered with Non-Targeted Ion Mobility Spectrometry-Mass Spectrometry.bioRxiv : the preprint server for biology · 2025Article
- Challenges in PFAS Postdegradation Analysis: Insights from the PFAS-CTAB Model System.ACS measurement science au · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Per- and polyfluoroalkyl substances (PFAS) are a class of thousands of man-made chemicals that are persistent and highly stable in the environment. Fish consumption has been identified as a key route of PFAS exposure for humans. However, routine fish monitoring targets only a handful of PFAS, and non-targeted analyses have largely only evaluated fish from heavily PFAS-impacted waters. Here, we evaluated PFAS in fish fillets from recreational and drinking water sources in central North Carolina to assess whether PFAS are present in these fillets that would not be detected by conventional targeted methods. We used liquid chromatography, ion mobility spectrometry, and mass spectrometry (LC-IMS-MS) to collect full scan feature data, performed suspect screening using an in-house library of 100 PFAS for high confidence feature identification, searched for additional PFAS features using non-targeted data analyses, and quantified perfluorooctanesulfonic acid (PFOS) in the fillet samples. A total of 36 PFAS were detected in the fish fillets, including 19 that would not be detected using common targeted methods, with a minimum of 6 and a maximum of 22 in individual fish. Median fillet PFOS levels were concerningly high at 11.6 to 42.3 ppb, and no significant correlation between PFOS levels and number of PFAS per fish was observed. Future PFAS monitoring in this region should target more of these 36 PFAS, and other regions not considered heavily PFAS contaminated should consider incorporating non-targeted analyses into ongoing fish monitoring studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.