Evidence map›Paper›PMID 39066528›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2024

Tongqiao Yizhi granule repress the nuclear factor kappa-b/nucleotide oligomerization domain-like receptors 3/caspase-1 pyroptosis pathway in the hippocampus to counter vascular dementia in rats.

L I Yanjiao, Hao Linyao, L I Shuangyang, Luo Yanqi, Wang Juan, Wang Raoqiong, Bai Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

L I YanjiaoCollege of Integrative Medicine, Southwest Medical University, Luzhou 646600, China.
Hao LinyaoCollege of Integrative Medicine, Southwest Medical University, Luzhou 646600, China.
L I ShuangyangDepartment of Neurology and National Traditional Chinese Medicine Clinical Research Base, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China.
Luo YanqiCollege of Integrative Medicine, Southwest Medical University, Luzhou 646600, China.
Wang JuanCollege of Integrative Medicine, Southwest Medical University, Luzhou 646600, China.
Wang RaoqiongDepartment of Neurology and National Traditional Chinese Medicine Clinical Research Base, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China.
Bai XueDepartment of Neurology and National Traditional Chinese Medicine Clinical Research Base, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China.

Funding

Luzhou Basic Application Project: the Mechanism of Tongqiao Yizhi Granules in the Treatment of Vascular Dementia by Regulating Gasdermin D-Mediated Pyroptosis 2020-JYJ-57Sichuan Provincial Administration of Traditional Chinese Medicine Science and Technology Special: Study on the Mechanism of Shexiang Huayu Xingnao Granules Reducing Nerve Injury in Cerebral Hemorrhage Model Rats by Regulating Microglia Polarization through Peroxisome Proliferator-activated Receptor γ 2021MS506Sichuan Provincial Science and Technology Department Applied Basic Research Project: a Dynamic Contrast Enhanced Magnetic Resonance Imaging-based Study on the Effect of Eind Medicine Kaixuan Method on Blood-brain Barrier Function and Prognosis in Patients with Small to Medium Volume Cerebral Hemorrhage 2020YJ0437
6 · The paper itself

Abstract

objectiveTo explore the mechanism by which Tongqiao Yizhi granule (, TQYZKL) intervenes pyroptosis to treat vascular dementia (VaD) in a rat model.

methodsThe rat model of VaD was established by two-vessel occlusion (2VO). The rats were randomly divided into Sham group, Model group, Nimodipine group, TQYZKL (6.2 g?kg

resultsThe study revealed that TQYZKL effectively improved the ability of VaD ratsto learn and memorize, relieved the pathological damage in the hippocampus, restored neuronal morphology, and reduced the expression of pyroptosis-related proteins P65, NLRP3, caspase-1, GSDMD-N, IL-18 and IL-1β (

conclusionTQYZKL inhibits neuronal pyroptosis in the hippocampus of VaD rats by regulating nuclear factor kappa-B/NLRP3/caspase-1 signaling pathway, thus exerting a therapeutic effect on VaD in the rats.

Indexed as

Caspase 1Dementia, VascularDrugs, Chinese HerbalHippocampusNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisAnimalsHumansMaleRatsRats, Sprague-DawleySignal TransductionCaspase 1Drugs, Chinese HerbalNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratcaspase 1dementia, vascularNF-kappa BNLR family, pyrin domain-containing 3 proteinpyroptosisTongqiao Yizhi granule

Identifiers

PMID39066528
PMCPMC11337261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.