Evidence map›Paper›PMID 39066496›Full record

ArticleJournal of applied microbiology2024

Agar and agarose used for Staphylococcus aureus biofilm cultivation impact fluoroquinolone tolerance.

Angela D Power, Wendy W K Mok

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Angela D PowerDepartment of Molecular Biology & Biophysics, UConn Health, Farmington, CT 06032, United States.
Wendy W K MokDepartment of Molecular Biology & Biophysics, UConn Health, Farmington, CT 06032, United States.

Funding

Mapping polymicrobial interactions that modulate antibiotic persistenceDP2GM146456 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MOK, WENDY W.K. · 2021 to 2021
$1.5M
NIGMS NIH HHS DP2 GM146456NIH HHS DP2GM146456-01
6 · The paper itself

Abstract

aimsStaphylococcus aureus is an opportunistic pathogen whose treatment is further complicated by its ability to form biofilms. In this study, we examine the impact of growing S. aureus biofilms on different polymerizing surfaces, specifically agar and agarose, on the pathogen's tolerance to fluoroquinolones. METHODS AND

resultsBiofilms of two methicillin-resistant strains of S. aureus were grown on agar or agarose in the presence of the same added nutrients, and their antibiotic susceptibility to two fluoroquinolones, moxifloxacin (MXF) and delafloxacin (DLX), were measured. We also compared the metabolism and extracellular polymeric substances (EPS) production of biofilms that were grown on agar and agarose.

conclusionsBiofilms that were grown on agarose were consistently more susceptible to antibiotics than those grown on agar. We found that in biofilms that were grown on agar, extracellular protein composition was higher, and adding EPS to agarose-grown biofilms increased their tolerance to DLX to levels that were comparable to agar-grown biofilms.

Indexed as

AgarAnti-Bacterial AgentsBiofilmsFluoroquinolonesMicrobial Sensitivity TestsSepharoseStaphylococcus aureusCulture MediaMethicillin-Resistant Staphylococcus aureusMoxifloxacinAgarAnti-Bacterial AgentsCulture MediaFluoroquinolonesMoxifloxacinSepharoseantibiotic treatment failurebiofilmsdelafloxacinfluoroquinolonesS. aureus

Identifiers

PMID39066496
PMCPMC11301810

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.