Evidence map›Paper›PMID 39066477›Full record

ArticleBiophysical journal2024

Assessing the mechanism of facilitated proton transport across GUVs trapped in a microfluidic device.

Dominik Ruppelt, Elena L M Ackermann, Tom Robinson, Claudia Steinem

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dominik RuppeltInstitute of Organic and Biomolecular Chemistry, Georg-August Universität Göttingen, Göttingen, Germany.
Elena L M AckermannInstitute of Organic and Biomolecular Chemistry, Georg-August Universität Göttingen, Göttingen, Germany.
Tom RobinsonInstitute for Bioengineering, School of Engineering, University of Edinburgh, Edinburgh, United Kingdom.
Claudia SteinemInstitute of Organic and Biomolecular Chemistry, Georg-August Universität Göttingen, Göttingen, Germany. Electronic address: csteine@gwdg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proton transport across lipid membranes is one of the most fundamental reactions that make up living organisms. In vitro, however, the study of proton transport reactions can be very challenging due to limitations imposed by proton concentrations, compartment size, and unstirred layers as well as buffer exchange and buffer capacity. In this study, we have developed a proton permeation assay based on the microfluidic trapping of giant vesicles enclosing the pH-sensitive dye pyranine to address some of these challenges. Time-resolved fluorescence imaging upon a rapid pH shift enabled us to investigate the facilitated H

Indexed as

Ion TransportLab-On-A-Chip DevicesProtonsUnilamellar LiposomesArylsulfonatesCarbonyl Cyanide m-Chlorophenyl HydrazoneGramicidinHydrogen-Ion ConcentrationArylsulfonatesCarbonyl Cyanide m-Chlorophenyl HydrazoneGramicidinProtonspyranineUnilamellar Liposomes

Identifiers

PMID39066477
PMCPMC11428277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.