Evidence map›Paper›PMID 39066255›Full record

ArticleViruses2024

Plant-Produced Chimeric Hepatitis E Virus-like Particles as Carriers for Antigen Presentation.

Eugenia S Mardanova, Egor A Vasyagin, Kira G Kotova, Gergana G Zahmanova, Nikolai V Ravin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eugenia S MardanovaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0003-2148-7658
Egor A VasyaginInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0009-0005-2535-1012
Kira G KotovaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.
Gergana G ZahmanovaDepartment of Molecular Biology, University of Plovdiv, 4000 Plovdiv, Bulgaria.ORCID 0000-0002-7667-9924
Nikolai V RavinInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0002-1456-1832

Funding

Bulgarian "Science and Education for Smart Growth" Operational Program BG05M2OP001-1.003-001-C01Ministry of Science and Higher Education of the Russian Federation 075-15-2022-318
6 · The paper itself

Abstract

A wide range of virus-like particles (VLPs) is extensively employed as carriers to display various antigens for vaccine development to fight against different infections. The plant-produced truncated variant of the hepatitis E virus (HEV) coat protein is capable of forming VLPs. In this study, we demonstrated that recombinant fusion proteins comprising truncated HEV coat protein with green fluorescent protein (GFP) or four tandem copies of the extracellular domain of matrix protein 2 (M2e) of influenza A virus inserted at the Tyr485 position could be efficiently expressed in

Indexed as

Antigen PresentationCapsid ProteinsHepatitis E virusNicotianaRecombinant Fusion ProteinsViral Matrix ProteinsGreen Fluorescent ProteinsHepatitis EInfluenza A virusPlants, Genetically ModifiedVaccines, Virus-Like ParticleViroporin ProteinsCapsid ProteinsGreen Fluorescent ProteinsM2 protein, Influenza A virusRecombinant Fusion ProteinsVaccines, Virus-Like ParticleViral Matrix ProteinsViroporin Proteinshepatitis E virusinfluenzaM2e peptideNicotiana benthamianatransient expressionvaccineviral vectorvirus-like particle

Identifiers

PMID39066255
PMCPMC11281382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.