Evidence map›Paper›PMID 39066247›Full record

ReviewViruses2024

Refractory/Resistant Cytomegalovirus Infection in Transplant Recipients: An Update.

Léna Royston, Genovefa A Papanicolaou, Dionysios Neofytos

Registry-linked trialAbstract readReview
In one paragraph

Review in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07679412 (An Exploratory Clinical Study of Autologous LB-DTK-CMV in Patients With Antiviral-Resistant and Refractory Cytomegalovirus Retinitis.), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07679412 narecruitingnot on this mapstarted 2026, after this paper: background citation

An Exploratory Clinical Study of Autologous LB-DTK-CMV in Patients With Antiviral-Resistant and Refractory Cytomegalovirus Retinitis.

TypeinterventionalSponsorLucasBioRan2026 to 2027Enrolled5ConditionsCMV RetinitisArmsLB-DTK-CMV
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Ganciclovir Resistance-Linked Mutations in the HCMVDiagnostics (Basel, Switzerland) · 2025
    Article
  2. A vaccine against cytomegalovirus: how close are we?The Journal of clinical investigation · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Léna RoystonDivision of Infectious Diseases, University Hospital of Geneva, 1211 Geneva, Switzerland.ORCID 0000-0003-2367-7682
Genovefa A PapanicolaouInfectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Dionysios NeofytosDivision of Infectious Diseases, University Hospital of Geneva, 1211 Geneva, Switzerland.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Despite the significant progress made, CMV infection is one of the most frequent infectious complications in transplant recipients. CMV infections that become refractory or resistant (R/R) to the available antiviral drugs constitute a clinical challenge and are associated with increased morbidity and mortality. Novel anti-CMV therapies have been recently developed and introduced in clinical practice, which may improve the treatment of these infections. In this review, we summarize the treatment options for R/R CMV infections in adult hematopoietic cell transplant and solid organ transplant recipients, with a special focus on newly available antiviral agents with anti-CMV activity, including maribavir and letermovir.

Indexed as

Antiviral AgentsCytomegalovirusCytomegalovirus InfectionsDrug Resistance, ViralTransplant RecipientsAcetatesDichlororibofuranosylbenzimidazoleHematopoietic Stem Cell TransplantationHumansOrgan TransplantationQuinazolinesAcetatesAntiviral AgentsDichlororibofuranosylbenzimidazoleletermovirmaribavirQuinazolinescytomegalovirus (CMV)letermovirmaribavirrefractory infectionresistant infectiontransplant recipients

Identifiers

PMID39066247
PMCPMC11281367

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.