Evidence map›Paper›PMID 39066217›Full record

ArticleViruses2024

Minocycline Inhibits Tick-Borne Encephalitis Virus and Protects Infected Cells via Multiple Pathways.

Mengtao Cao, Wei Yang, Jintao Yang, Yanli Zhao, Xiaoyu Hu, Xiaoli Xu, Jing Tian, Yue Chen, Hongxia Jiang, Ruiwen Ren and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengtao CaoCenter for Disease Control and Prevention of Southern Theater Command, Guangzhou 510507, China.
Wei YangGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Jintao YangGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Yanli ZhaoGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Xiaoyu HuCenter for Disease Control and Prevention of Southern Theater Command, Guangzhou 510507, China.
Xiaoli XuInstrument Analysis & Research Center, South China Agricultural University, Guangzhou 510642, China.
Jing TianCenter for Disease Control and Prevention of Southern Theater Command, Guangzhou 510507, China.
Yue ChenCenter for Disease Control and Prevention of Southern Theater Command, Guangzhou 510507, China.ORCID 0000-0003-0105-7546
Hongxia JiangGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0002-8349-2877
Ruiwen RenCenter for Disease Control and Prevention of Southern Theater Command, Guangzhou 510507, China.
Chunyuan LiCenter for Disease Control and Prevention of Southern Theater Command, Guangzhou 510507, China.ORCID 0009-0000-7884-8085

Funding

Guangdong Province Science and Technology Library 2016A020219006Guangdong Province Science and Technology Library 2022A1515011132
6 · The paper itself

Abstract

Tick-borne Encephalitis (TBE) is a zoonotic disease caused by the Tick-borne Encephalitis virus (TBEV), which affects the central nervous system of both humans and animals. Currently, there is no specific therapy for patients with TBE, with symptomatic treatment being the primary approach. In this study, the effects of minocycline (MIN), which is a kind of tetracycline antibiotic, on TBEV propagation and cellular protection in TBEV-infected cell lines were evaluated. Indirect immunofluorescence, virus titers, and RT-qPCR results showed that 48 h post-treatment with MIN, TBEV replication was significantly inhibited in a dose-dependent manner. In addition, the inhibitory effect of MIN on different TBEV multiplicities of infection (MOIs) in Vero cells was studied. Furthermore, the transcriptomic analysis and RT-qPCR results indicate that after incubation with MIN, the levels of TBEV and

Indexed as

Encephalitis Viruses, Tick-BorneMinocyclineVirus ReplicationAnimalsAntiviral AgentsCell LineChlorocebus aethiopsEncephalitis, Tick-BorneHumansSignal TransductionVero CellsAntiviral AgentsMinocyclinecalcium ionIL-6MAPK-ERKminocyclineTBEV

Identifiers

PMID39066217
PMCPMC11281541

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.